Comparison 3. Factor Xa inhibitors versus VKA: dose of Factor Xa inhibitor.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Stroke and other systemic embolic events	12	64283	Odds Ratio (M‐H, Fixed, 95% CI)	0.93 [0.85, 1.01]
1.1 Apixaban 2.5mg twice daily	2	979	Odds Ratio (M‐H, Fixed, 95% CI)	0.45 [0.23, 0.90]
1.2 Apixaban 5 mg twice daily	2	17518	Odds Ratio (M‐H, Fixed, 95% CI)	0.81 [0.67, 0.98]
1.3 Edoxaban 30mg once daily	4	14964	Odds Ratio (M‐H, Fixed, 95% CI)	1.14 [0.98, 1.33]
1.4 Edoxaban 45mg once daily	1	259	Odds Ratio (M‐H, Fixed, 95% CI)	2.82 [0.11, 69.87]
1.5 Edoxaban 60mg once daily	4	14965	Odds Ratio (M‐H, Fixed, 95% CI)	0.87 [0.74, 1.02]
1.6 Edoxaban 30mg twice daily	1	494	Odds Ratio (M‐H, Fixed, 95% CI)	1.02 [0.20, 5.13]
1.7 Edoxaban 60mg twice daily	1	430	Odds Ratio (M‐H, Fixed, 95% CI)	0.46 [0.05, 4.46]
1.8 Rivaroxaban 10mg once daily	1	781	Odds Ratio (M‐H, Fixed, 95% CI)	1.03 [0.38, 2.78]
1.9 Rivaroxaban 15mg once daily	1	1136	Odds Ratio (M‐H, Fixed, 95% CI)	0.34 [0.14, 0.85]
1.10 Darexaban 15mg twice daily	1	486	Odds Ratio (M‐H, Fixed, 95% CI)	1.0 [0.09, 11.11]
1.11 Darexaban 30mg once daily	2	669	Odds Ratio (M‐H, Fixed, 95% CI)	1.01 [0.09, 11.18]
1.12 Darexaban 30mg twice daily	1	486	Odds Ratio (M‐H, Fixed, 95% CI)	1.0 [0.09, 11.11]
1.13 Darexaban 60mg once daily	2	674	Odds Ratio (M‐H, Fixed, 95% CI)	1.55 [0.25, 9.59]
1.14 Darexaban 60mg twice daily	1	486	Odds Ratio (M‐H, Fixed, 95% CI)	2.01 [0.28, 14.42]
1.15 Darexaban 120mg once daily	2	673	Odds Ratio (M‐H, Fixed, 95% CI)	1.00 [0.15, 6.62]
1.16 Darexaban 240mg	1	172	Odds Ratio (M‐H, Fixed, 95% CI)	3.66 [0.15, 91.07]
1.17 Idraparinux 1,5mg once weekly	1	68	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.18 Idraparinux 2,5mg once weekly	1	4508	Odds Ratio (M‐H, Fixed, 95% CI)	0.67 [0.37, 1.21]
1.19 Betrixaban 40 mg	1	254	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.20 Betrixaban 60 mg	1	254	Odds Ratio (M‐H, Fixed, 95% CI)	3.02 [0.12, 74.93]
1.21 Betrixaban 80 mg	1	254	Odds Ratio (M‐H, Fixed, 95% CI)	3.02 [0.12, 74.93]
1.22 Idrabiotaparinux 3mg once weekly	1	3773	Odds Ratio (M‐H, Fixed, 95% CI)	0.91 [0.49, 1.67]
2 Major bleedings	11	63950	Odds Ratio (M‐H, Fixed, 95% CI)	0.70 [0.65, 0.75]
2.1 Apixaban 2.5mg twice daily	2	973	Odds Ratio (M‐H, Fixed, 95% CI)	0.67 [0.38, 1.16]
2.2 Apixaban 5mg twice daily	2	17460	Odds Ratio (M‐H, Fixed, 95% CI)	0.70 [0.61, 0.82]
2.3 Edoxaban 30mg once daily	4	14741	Odds Ratio (M‐H, Fixed, 95% CI)	0.46 [0.40, 0.54]
2.4 Edoxaban 45mg once daily	1	259	Odds Ratio (M‐H, Fixed, 95% CI)	6.68 [0.34, 130.64]
2.5 Edoxaban 60mg once daily	4	14918	Odds Ratio (M‐H, Fixed, 95% CI)	0.79 [0.69, 0.90]
2.6 Edoxaban 30mg twice daily	1	494	Odds Ratio (M‐H, Fixed, 95% CI)	5.21 [0.60, 44.92]
2.7 Edoxaban 60mg twice daily	1	430	Odds Ratio (M‐H, Fixed, 95% CI)	8.59 [1.02, 71.95]
2.8 Darexaban 15mg twice daily	1	486	Odds Ratio (M‐H, Fixed, 95% CI)	0.25 [0.03, 1.98]
2.9 Darexaban 30mg once daily	2	669	Odds Ratio (M‐H, Fixed, 95% CI)	0.12 [0.01, 2.01]
2.10 Darexaban 30mg twice daily	1	486	Odds Ratio (M‐H, Fixed, 95% CI)	0.75 [0.20, 2.85]
2.11 Darexaban 60mg once daily	2	674	Odds Ratio (M‐H, Fixed, 95% CI)	0.49 [0.10, 2.34]
2.12 Darexaban 60mg twice daily	1	486	Odds Ratio (M‐H, Fixed, 95% CI)	1.26 [0.40, 3.91]
2.13 Darexaban 120mg once daily	2	674	Odds Ratio (M‐H, Fixed, 95% CI)	0.99 [0.29, 3.35]
2.14 Darexaban 240mg once daily	1	172	Odds Ratio (M‐H, Fixed, 95% CI)	3.66 [0.15, 91.07]
2.15 Rivaroxaban 10mg once daily	1	780	Odds Ratio (M‐H, Fixed, 95% CI)	1.55 [0.71, 3.36]
2.16 Rivaroxaban 15mg once daily	1	1137	Odds Ratio (M‐H, Fixed, 95% CI)	0.80 [0.43, 1.49]
2.17 Betrixaban 40 mg	1	254	Odds Ratio (M‐H, Fixed, 95% CI)	0.09 [0.00, 1.60]
2.18 Betrixaban 60 mg	1	254	Odds Ratio (M‐H, Fixed, 95% CI)	0.09 [0.00, 1.60]
2.19 Betrixaban 80 mg	1	254	Odds Ratio (M‐H, Fixed, 95% CI)	0.59 [0.14, 2.52]
2.20 Idrabiotaparinux 3mg once weekly	1	3773	Odds Ratio (M‐H, Fixed, 95% CI)	0.92 [0.52, 1.63]
2.21 Idraparinux 1.5/2.5mg once weekly	1	4576	Odds Ratio (M‐H, Fixed, 95% CI)	2.62 [1.70, 4.03]