Comparison 4. Factor Xa inhibitors versus VKA: previous stroke or TIA.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Stroke and other systemic embolic events	5	59247	Odds Ratio (M‐H, Fixed, 95% CI)	0.86 [0.78, 0.94]
1.1 Previous stroke or TIA	5	18721	Odds Ratio (M‐H, Fixed, 95% CI)	0.87 [0.76, 1.00]
1.2 No previous stroke or TIA	5	40526	Odds Ratio (M‐H, Fixed, 95% CI)	0.85 [0.74, 0.97]
2 Major bleedings	4	54615	Odds Ratio (M‐H, Fixed, 95% CI)	0.75 [0.70, 0.81]
2.1 Previous stroke or TIA	4	17616	Odds Ratio (M‐H, Fixed, 95% CI)	0.79 [0.69, 0.90]
2.2 No previous stroke or TIA	4	36999	Odds Ratio (M‐H, Fixed, 95% CI)	0.73 [0.67, 0.80]