Comparison 5. Factor Xa inhibitors versus VKA: quality of anticoagulation with VKA (TTR).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Stroke and other systemic embolic events	3	52695	Odds Ratio (M‐H, Fixed, 95% CI)	0.85 [0.77, 0.94]
1.1 Good quality	3	27714	Odds Ratio (M‐H, Fixed, 95% CI)	0.89 [0.77, 1.04]
1.2 Bad quality	3	24981	Odds Ratio (M‐H, Fixed, 95% CI)	0.81 [0.70, 0.93]
2 Major bleedings	3	52730	Odds Ratio (M‐H, Fixed, 95% CI)	0.74 [0.68, 0.80]
2.1 Good quality	3	22288	Odds Ratio (M‐H, Fixed, 95% CI)	0.80 [0.72, 0.90]
2.2 Bad quality	3	30442	Odds Ratio (M‐H, Fixed, 95% CI)	0.69 [0.62, 0.77]