Date	Event	Description
29 August 2017	New search has been performed	We performed updated literature searches of the Cochrane Stroke Group and the Cochrane Heart Group Trials Registers (September 2016), the Cochrane Central Register of Controlled Trials (CENTRAL) (August 2017), MEDLINE (1950 to April 2017) and Embase (1980 to April 2017). We have added three new trials that included 25,064 people. We have now included data from 67,688 people randomised into 13 trials.
24 April 2017	New citation required but conclusions have not changed	No changes in main conclusions of this updated review compared with the previous version (2013).