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. 2019 Jan 17;37(7):580–588. doi: 10.1200/JCO.18.00889

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FIG A5. — Dose transition pathways (DTP) flow diagrams. Flow diagrams presenting the different pathways for dose (d) recommendations on the basis of the possible patient outcome permutations within the trial for future cohorts (C). (A) DTP for C3 to C5 on the basis of no observed DLTs for C1 and C2: (zero of three at dose 0 and zero of three at dose 1). The recommended dose for C3 is dose 2. The DTP for subsequent cohorts only apply if the cohort size is three at the recommended dose. (B, C) Two scenarios where this is not the case. (B) Scenario in which C3 consist of two patients who received dose level 2 and one patient received dose level 3, with no dose-limiting toxicities (DLTs) experienced. (C) Scenario in which C3 consist of two patients who received dose level 2 and one patient received dose level 3, with no DLT at dose level 2 but a DLT experienced by the patient who received dose level 3.