Trial identification	Title	Language	Translator/s	Reasons for rejection
Trentalancia 1967	The use of 5‐oxytryptamine in post‐extraction haemorrhages	Italian	Giovanni Lodi	1. The study is not randomised. Randomisation is never mentioned. The author stated that "the patients have been divided as follows" (page 1386). 2. Patients were at risk of bleeding, and not with post‐extraction bleeding.
Pavek 1976	Evaluation of the haemostatic effect of Dicynon in dentoalveolar surgery	Czech	Andrea Pokorna	The study does not fulfil criteria as it describes application of Dicynone in four groups of patients – no randomisation, no detailed description of the patient groups.
Szpirglas 1979	Stomatological haemorrhages; haemostasis with GRF (gelatin‐resorcin‐formol)	Italian	Maddalena Manfredi	This study is a description of a topical haemostasis technique without any report about patients.
Marini 1966	Therapy of post‐extraction haemorrhages in haemophiliac patients with epsilon‐aminocaproic acid (EACA).	Italian	Maddalena Manfredi	This is a case series.
Torteli 1965	Use of "reptilase" in postoperative haemorrhage of the dental apparatus	German	Ubai Alsharif	This is a case series of 14 patients who were treated with Raptilase, and does not fulfil the inclusion criteria.
Zhou 1985	Prevention and treatment of haemorrhage after extraction of teeth by using the pulvis of cibotium barometz‐alum burn	Chinese	Dr Liyuan Ma, Professors Chengge Hua, Zongdao Shi and Mr.Loh Zheng Tao	The trial is a RCT with two arms; however, the randomisation method is not reported. This is a preventive study for reducing post‐extraction complications including PEB, instead of managing post‐extraction bleeding.
Antoszewski 1972	Cepevit‐K preparation in controlling haemorrhages and bleeding following tooth extraction	Polish	Joanna Zajac and Malgorzata Bala	Not a randomised controlled trial. They used Cepevit‐K: ‐ after extraction for 22 patients (for 17, bleeding was stopped within eight minutes; chirurgical treatment was provided for the others). ‐ two days before extraction in 18 patients with low coagulation time (for four patients in this group, additional chirurgical treatment was needed). The only comparison is 20 other people with bleeding after tooth extraction, where the author used other techniques (other than chirurgical treatment); it only worked for eight patients, so the other 12 were given Cepevit‐K.
Fetkowska‐Mielnik 1969	Clinical evaluation of the results of treatment of post‐extraction bleeding with new drugs E.A.C.A., styptanon	Polish	Joanna Zajac and Malgorzata Bala	Not a randomised controlled trial. Study was based on observation of 69 patients, all with blood coagulation problems: some after extraction with bleeding, some before extraction. For all blood analyses were done and according to results: ‐ for some: epsilon aminocaproic acid (EACA) was used ‐ for others: Styptanon was used ‐ for others: EACA and Styptanon together
Khomiachenko 1978	Use of aminocaproic acid for stopping the haemorrhage after tooth extraction	Russian	Lilia Ziganshina and Anna Misyail Abdul Rashid	This is an abstract describing 100% success of 5% aminocapronic acid in 135 patients. This was not a trial; there was no comparison.
Neuner 1968	Therapy of haemorrhage following extractions	German	Karin Rau and Anette Bluemle	This is not a randomised control trial. In this publication, the interventions for post‐extraction bleeding are explained in detail, but not within the scope of a clinical study.
Saltykova 1974	The use of new haemostatic drug in dental practice	Russian	Lilia Ziganshina and Anna Misyail Abdul Rashid	This is a single case report.
Martineau 1989	Hemorrhage in the dental office. Study of local haemostatic treatment	French	Paul Tramini	This paper is just a recommendation for practitioners and students in case of PEB problems. No data are available.
Rokicka‐Milewska 1966	Application of epsilon‐aminocaproic acid for oral mucosal bleeding in haemophiliacs	Polish	Joanna Zajac and Malgorzata Bala	This article is not a RCT. All participants (13 children with haemophilia: nine type A and four type B) received epsilon‐aminocaproic (20% solution) acid 24 hours before tooth extraction. Intolerance developed in some children, so the dose was changed (from 0.1 g/kg of body weight to 0.05g/kg), or the drug was administered intravenously.