Comparison 2. Alpha‐2 adrenergic agonists versus control in cardiac surgery.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All‐cause mortality	16	1947	Risk Ratio (M‐H, Fixed, 95% CI)	0.52 [0.26, 1.04]
2 Myocardial infarction	8	782	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.43, 2.40]
3 Myocardial ischaemia	13	1134	Risk Ratio (M‐H, Fixed, 95% CI)	0.69 [0.56, 0.86]
4 Supraventricular tachyarrhythmia	6	1044	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.50, 1.16]
5 Heart failure	4	549	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.49, 1.63]
6 Acute stroke	7	1175	Risk Ratio (M‐H, Fixed, 95% CI)	0.37 [0.15, 0.93]
7 Bradycardia	10	1477	Risk Ratio (M‐H, Fixed, 95% CI)	1.88 [1.35, 2.62]
8 Hypotension	9	1413	Risk Ratio (M‐H, Random, 95% CI)	1.19 [0.87, 1.64]