Comparison 4. Alpha‐2 adrenergic agonists (stratified by drug) versus control in non‐cardiac surgery.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All‐cause mortality	16	14081	Risk Ratio (M‐H, Fixed, 95% CI)	0.80 [0.61, 1.04]
1.1 Clonidine	7	10787	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.64, 1.23]
1.2 Dexmedetomidine	7	1097	Risk Ratio (M‐H, Fixed, 95% CI)	0.49 [0.15, 1.58]
1.3 Mivazerol	2	2197	Risk Ratio (M‐H, Fixed, 95% CI)	0.69 [0.42, 1.15]
2 Cardiac mortality	5	12525	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.60, 1.23]
2.1 Clonidine	3	10328	Risk Ratio (M‐H, Fixed, 95% CI)	1.12 [0.71, 1.75]
2.2 Mivazerol	2	2197	Risk Ratio (M‐H, Fixed, 95% CI)	0.51 [0.27, 0.98]
3 Myocardial infarction	12	13907	Risk Ratio (M‐H, Random, 95% CI)	0.94 [0.69, 1.27]
3.1 Clonidine	6	10756	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.57, 1.92]
3.2 Dexmedetomidine	4	954	Risk Ratio (M‐H, Random, 95% CI)	0.55 [0.20, 1.49]
3.3 Mivazerol	2	2197	Risk Ratio (M‐H, Random, 95% CI)	0.60 [0.17, 2.08]
4 Hypotension	15	13738	Risk Ratio (M‐H, Random, 95% CI)	1.24 [1.03, 1.48]
4.1 Clonidine	7	10485	Risk Ratio (M‐H, Random, 95% CI)	1.29 [1.23, 1.35]
4.2 Dexmedetomidine	6	1056	Risk Ratio (M‐H, Random, 95% CI)	1.81 [1.07, 3.06]
4.3 Mivazerol	2	2197	Risk Ratio (M‐H, Random, 95% CI)	0.95 [0.82, 1.10]