Corbett 2005.

Methods	Randomized controlled trial comparing dexmedetomidine versus propofol.
Participants	89 people undergoing non‐emergent CABG surgery with an expected length of intubation < 24 hr. Age (yr): mean (SD): 63 (10.4). Sex: 73 men, 16 women Exclusion criteria: hypersensitivity to either drug or any component of drugs; severe hypotension immediately before initiation of study drug; HR 40 bpm immediately before initiation of study drug; renal insufficiency; hepatic dysfunction; requirement for continued neuromuscular blocking agents postoperatively; requirement for epidural or spinal anaesthesia; gross obesity; history of alcohol or drug abuse. Participants withdrawn from study if length of intubation exceeded 48 hr.
Interventions	Dexmedetomidine 1 μg/kg IV loading dose then 0.4 μg/kg/hr infusion, beginning immediately after surgery. Propofol 0.2‐0.7 μg/kg/hr IV infusion.
Outcomes	All‐cause mortality. Supraventricular tachyarrhythmia.
Notes	Funding: Society of Critical Care Medicine, Clinical Pharmacy and Pharmacology Section, Ortho‐Biotech Fellowship Grant, and departmental funds. Declaration of interest: not stated. Recruitment dates: October 2002 to April 2004.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Authors described use of random‐number table.
Allocation concealment (selection bias)	High risk	Methods of concealment not discussed. Allocation took place in operating room at end of operation.
Blinding of participants and personnel (performance bias) All outcomes	High risk	Open‐label.
Blinding of outcome assessment (detection bias) All outcomes	High risk	Open‐label.
Incomplete outcome data (attrition bias) All outcomes	Low risk	All data reported.
Selective reporting (reporting bias)	High risk	Do not discuss length of intubation or ICU stay as outcomes in methods; however, they were reported.
Other bias	Low risk	None.