Comparison 1. Folic acid supplementation versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Acute splenic sequestration	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
1.2 Painful episodes	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
1.3 Minor Infections	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
1.4 Major Infection	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
1.5 Dactylitis	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected