Database	Date of Search	Search terms
PubMed	31 July 2015	#1 folic acid[MeSH] OR Folic Acid Deficiency [Mesh] OR folic acid[tw] OR folate[tw] OR vitamin B9[tw] OR B9 vitamin[tw] OR vitamin B‐9[tw] OR metafolin[tw] OR levomefolate[tw] OR folvite [tw] OR folacin [tw] OR 5‐methyltetrahydrofolate[tw] OR 5‐methylTHF[tw] OR 5‐MTHF[tw] OR L‐5‐MTHF[tw] #2 anaemia, sickle cell[MeSH] OR sickle cell[tw] OR haemoglobin S*[tw] OR HbS disease[tw] #3 (randomized controlled trial [pt] OR controlled clinical trial [pt] OR randomized [tiab] OR placebo [tiab] OR drug therapy [sh] OR randomly [tiab] OR trial [tiab] OR groups [tiab]) NOT (animals [mh] NOT humans [mh]) #1 AND #2 AND #3 Results: 73