Kim‐Shapiro 2014.

Study name	Study of Beet Juice for Patients With Sickle Cell Anemia (NCT02162225).
Methods	Phase 2 clinical trial. Single group assignment.
Participants	Adults with sickle cell anaemia.
Interventions	Beet juice (dietary provision of folate).
Outcomes	Safety of intervention.
Starting date	June 2014.
Contact information	Natalia Dixon, MD ndixon@wakehealth.edu.
Notes	While we were unable to identify any ongoing randomised controlled trials involving folic acid supplementation or folate provision through diet, we did identify a Phase 2 clinical trial investigating the safety of beet juice (“Unbeetable”) in adults with sickle cell anemia (Kim‐Shapiro NCT02162225). The trial is focused on the provision of nitrates through the beet juice, however, the beet juice also contains a substantial quantity of folate (23% ‐ 46% of daily value, depending on amount consumed). As the trial may ultimately progress to a Phase 3 RCT, it is important to document in this review as potential future research. Note: on 08 November 2017 this trial was suspended due to the fact that enrolment was very slow. The investigators hope to reopen as multi‐site study.