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. 2018 Mar 1;2018(3):CD001120. doi: 10.1002/14651858.CD001120.pub3

Melendez 2015.

Methods Cluster RCT.
Participants 30 participants with AD according to DSM‐IV with MMSE scores < 19 who were attending day centres in Valencia, Spain.
Mean age: 84.2 years.
Interventions Intervention: group RT.
Control: treatment as usual.
Outcomes Cognitive: AMI.
Length and frequency of intervention 2 × 30‐minute sessions per week for 10 weeks.
Time points measured Paper stated, "pre‐test, post‐test and 2‐month follow‐up tests were performed."
Number of participants who did not complete study 2/30 (6.66%).
Notes Study also recruited participants with amnestic MCI but data from these participants were excluded from the present review.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Cluster randomisation. Paper reported, "The day centres were randomised to determine where the intervention programme would be administered. To randomise the groups, the names of centres were introduced into a spreadsheet and programme output file presented name of centre to receive treatment."
Allocation concealment (selection bias) Low risk Randomised on level of day centre. Allocation decided using spreadsheet and corresponding programme output file.
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Unclear who interviewed participants, but they were recorded and 2 psychologists then independently analysed the scores.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 1 participant from each group dropped out. The participant from the reminiscence intervention left the day centre to be "institutionalised." Reason for control drop out unspecified. ITT analysis completed.
Selective reporting (reporting bias) Low risk All outcomes listed in the methods section were reported and there was no evidence of selective outcome reporting.
Other bias Unclear risk Cluster RCT. The study had 2 clusters but was not large enough to apply the methods detailed in the Cochrane Handbook for Systematic Reviews of Interventions to reduce it to its effective sample size. No evidence of baseline imbalanced, missing clusters from the analysis or recruitment bias.
Availability of training and supervision 
 Objective outcome measures Low risk Led by a psychologist. Author stated by email that "an official master gerontologist" oversaw the teaching and training of the reminiscence processes.
Availability of manual or protocol for intervention 
 All outcomes Low risk Clear protocol outlined in the paper.