CBT versus unspecific control conditions
Analysis		Name	Control	MD	95% CI		% change
Analysis 1.1 ADHD symptoms (observer)	1.1.1	Solanto 2010	73.19	−6.25	−11.04	−1.46	−9% (95% CI −15 to −2)
	1.1.2a	Hepark 2015	28.00	−6.5	−9.77	−3.23	−23% (95% CI −35 to −12)
	1.1.2b	Stevenson 2002	112.9	−39.2	−52.76	−25.64	−35% (95% CI −47 to −23)
Analysis 1.2 ADHD symptoms (self‐reported)	1.2.1a	Hirvikoski 2011	27.28	−2.81	−8.02	2.4	−10% (95% CI −29 to 9)
	1.2.1b	Solanto 2010	76.8	−1.00	−6.15	4.15	−1% (95% CI −8 to 5)
	1.2.2a	Gu 2017	71.77	−11.06	−15.75	−6.37	−15% (95% CI −22 to −9)
	1.2.2b	Hepark 2015	28.8	−5.8	−8.86	−2.74	−20% (95% CI −31 to −10)
	1.2.2c	Pettersson 2017	29.72	−2.38	−8.11	3.35	−8% (95% CI −27 to 11)
	1.2.2d	Schoenberg 2014	31.3	−8.3	−12.53	−4.07	−27% (95% CI −40 to −13)
	1.2.2e	Virta 2010	−4.6	−8.7	−17.47	0.07	189% (95% CI −2 to 380)
Analysis 1.3 Inattention (clinician)	1.3.1	Solanto 2010	16.18	−2.47	−4.43	−0.51	−15% (95% CI −27 to −3)
	1.3.2	Hepark 2015	16.5	−4.1	−6.00	−2.2	−25% (95% CI −36 to −13)
Analysis 1.4 Inattention (self‐reported)	1.4.1a	Gu 2017	64.23	−12.59	−17.53	−7.65	−20% (95% CI −27 to −12)
	1.4.1b	Hepark 2015	16.1	−3.3	−5.02	−1.58	−20% (95% CI −31 to −10)
	1.4.2c	Moëll 2015	27.93	−5.01	−7.16	−2.86	−18% (95% CI −26 to −10)
	1.4.2d	Schoenberg 2014	17.4	−5.2	−7.47	−2.93	−30% (95% CI −43 to −17)
Analysis 1.5 Hyperactivity‐impulsivity (clinician)	1.5.1	Hepark 2015	11.5	−2.5	−4.63	−0.37	−22% (95% CI −40 to −3)
Analysis 1.6 Hyperactivity‐impulsivity (self‐reported)	1.6.1a	Gu 2017	71.15	−10.29	−14.91	−5.67	−14% (95% CI −21 to −8)
	1.6.1b	Hepark 2015	12.6	−2.3	−4.28	0.32	−18% (95% CI −34 to 3)
	1.6.1c	Moëll 2015	20.85	−1.31	−4.81	2.19	−6% (95% CI −23 to 11)
	1.6.1d	Schoenberg 2014	14.00	−3.2	−6.05	−0.35	−23% (95% CI −43 to −3)
Analysis 1.7 Depression (self‐reported)	1.7.1	Solanto 2010	9.08	0.58	−2.8	3.96	6% (95% CI −31 to 44)
	1.7.2a	Gu 2017	9.42	−2.35	−4.01	−0.69	−25% (95% CI −43 to −7)
	1.7.2b	Hepark 2015	11.8	−2.7	−6.51	1.11	−23% (95% CI −55 to 9)
	1.7.2c	Moëll 2015	7.7	−1.08	−3.48	1.32	−14% (95% CI −45 to 17)
	1.7.2d	Pettersson 2017	15.11	−1.92	−8.63	4.79	−13% (95% CI −57 to 32)
	1.7.2e	Virta 2010	−1.5	−3.1	−10.22	4.02	207% (95% CI −268 to 681)
Analysis 1.8 Anxiety (clinician)	1.8.1	Solanto 2010	8.88	−0.81	−3.21	1.59	−9% (95% CI −36 to 18)
Analysis 1.9 Anxiety (self‐reported)	1.9.1a	Gu 2017	15.08	−5.58	−8.97	−2.19	−37% (95% CI −59 to −15)
	1.9.1b	Hepark 2015	90.8	−12.3	−22.56	−2.04	−14% (95% CI −25 to −2)
	1.9.1c	Moëll 2015	8.81	−0.85	−2.67	0.97	−10% (95% CI −30 to 11)
	1.9.1d	Pettersson 2017	15.22	−1.55	−8.04	4.94	−10% (95% CI −53 to 32)
Analysis 1.10 State anger (self‐reported)	1.10.1	Stevenson 2002	14.00	−3.3	−5.62	−0.98	−24% (95% CI −40 to −7)
Analysis 1.11 Trait anger (self‐reported)	1.11.1	Stevenson 2002	24.3	−3.8	−7.63	0.03	−16% (95% CI −31 to 0)
Analysis 1.12 Self‐steem (self‐reported)	1.12.1	Solanto 2010	−1.3	0.00	−1.85	1.85	0% (95% CI −142 to 142)
	1.12.2	Stevenson 2002	97.4	12.4	4.55	20.25	13% (95% CI 5 to 21)
Analysis 1.13 Qualfeity of life (self‐reported)	1.13.1a	Pettersson 2017	41.91	4.99	−6.23	16.21	12% (95% CI −15 to 39)
	1.13.1b	Virta 2010	59.2	1.7	−14.7	18.1	3% (95% CI −25 to 31)
CBT plus pharmacotherapy versus pharmacotherapy alone
Analysis		Name	Control	MD	95% CI		% change
Analysis 2.1 ADHD symptoms (clinician)	2.1a	Emilsson 2011	35.94	−6.06	−10.01	−2.11	−17% (95% CI −28 to −6)
	2.1b	Safren 2005	20.8	−5.61	−12.11	0.89	−27% (95% CI −58 to 4)
Analysis 2.2 ADHD symptoms (self‐reported)	2.2a	Emilsson 2011	23.47	−6.25	−11.72	−0.78	−27% (95% CI −50 to −3)
	2.2b	Safren 2005	23.87	−9.12	−15.69	−2.55	−38% (95% CI −66 to −11)
Analysis 2.3 Inattention (self‐reported)	2.3	Emilsson 2011	14.71	−4.54	−7.75	−1.33	−31% (95% CI −53 to −9)
Analysis 2.4 Hyperactivity‐impulsivity (self‐reported)	2.4	Emilsson 2011	8.76	−1.7	−5.29	1.89	−19% (95% CI −60 to 22)
Analysis 2.5 Clinical Global Impression (clinician)	2.5a	Emilsson 2011	3.88	−0.7	−1.31	−0.09	−18% (95% CI −34 to −2)
	2.5b	Safren 2005	4.13	−0.82	−1.51	−0.13	−20% (95% CI −37 to −3)
Analysis 2.6 Depression (clinician)	2.6	Safren 2005	10.00	−5.56	−9.71	−1.41	−56% (95% CI −97 to −14)
Analysis 2.7 Depression (self‐reported)	2.7a	Emilsson 2011	15.41	−8.19	−13.76	−2.62	−53% (95% CI −89 to −17)
	2.7b	Safren 2005	12.4	−4.77	−9.19	−0.35	−38% (95% CI −74 to −3)
Analysis 2.8 Anxiety (clinician)	2.8	Safren 2005	12.93	−5.68	−10.32	−1.04	−44% (95% CI −80 to −8)
Analysis 2.9 Anxiety (self‐reported)	2.9a	Emilsson 2011	15.29	−4.29	−11.36	2.78	−28% (95% CI −74 to 18)
	2.9b	Safren 2005	7.2	−3.51	−6.53	−0.49	−49% (95% CI −91 to −7)
CBT versus other specific interventions
Analysis		Name	Control	MD	95% CI		% change
Analysis 3.1 ADHD symptoms (clinician)	3.1.1	Safren 2010	19.19	−4.73	−8.79	−0.67	−25 (95% CI −46 to −3)
	3.1.2	Virta 2010	−4.50	−0.8	−1.6	0	18% (95% CI 0 to 36)
Analysis 3.2 ADHD symptoms (self‐reported)	3.2.1	Safren 2010	19.12	−7.28	−11.68	−2.88	−38% (95% CI −61 to −15)
	3.2.2	Virta 2010	−10.55	−2.75	−14.93	9.43	26% (95% CI −89 to 142)
	3.2.3	Vidal Estrada 2013	24.29	1.31	−5.92	8.54	5% (95% CI −24 to 35)
	3.2.4	Fleming 2015	75.56	−15.27	−29.52	−1.02	−20% (95% CI −39 to −1)
Analysis 3.3 Inattention (self‐reported)	3.3.1	Vidal Estrada 2013	18.58	1.35	−4.62	7.32	7% (95% CI −25 to 39)
	3.3.2	Fleming 2015	20.94	−2	−5.42	1.42	−10% (95% CI −26 to 7)
Analysis 3.4 Hyperactivity	3.4.1	Vidal Estrada 2013	13.88	1.72	−4.41	7.85	12% (95% CI −32 to 57)
Analysis 3.5 Impulsivity	3.5.1	Vidal Estrada 2013	14.76	2.84	−3.26	8.94	19% (95% CI −22 to 61)
Analysis 3.6 Clinical Global Impression (clinician)	3.6.1	Safren 2010	3.73	−0.53	−1.09	0.03	−14% (95% CI −29 to −1)
	3.6.2	Vidal Estrada 2013	4.15	0.18	−0.19	0.55	4% (95% CI −5 to 13)
Analysis 3.7 Clinical Global Impression (self‐reported)	3.7.1	Vidal Estrada 2013	4.17	0.29	−0.32	0.9	7% (95% CI −8 to 22)
Analysis 3.8 Depression (self‐reported)	3.8.1	Virta 2010	−1.67	−2.93	−8.88	3.02	175% (95% CI −181 to 532)
	3.8.2	Vidal Estrada 2013	13.64	−1.24	−9.37	6.89	−9% (95% CI −69 to 51)
	3.8.3	Fleming 2015	13.56	−2.91	−8.42	2.6	−21 (95% CI −62 to 19)
Analysis 3.9 Anxiety (self‐reported)	3.9.1	Vidal Estrada 2013	29.42	−4.22	−12.48	4.04	−14% (95% CI −42 to 14)
	3.9.2	Fleming 2015	15.75	−5.93	−12.91	1.05	−38% (95% CI −82 to 7)
Analysis 3.10 Qualfeity of life (self‐reported)	3.10.1	Virta 2010	65.20	−4.3	−17.31	8.71	−7% (95% CI −27 to 13)
	3.10.2	Vidal Estrada 2013	207.35	33.14	−35.76	102.04	16% (95% CI −17 to 49)
	3.10.3	Fleming 2015	52.8	14.29	6.13	22.45	27% (95% CI 12 to 43)