Study	Reason for exclusion
Ahlstrom 2011	Not RCT
Bellver 2015	No outcome of interest ‐ No control group with no metabolomics‐ Not RCT
Ciepiela 2015	Not RCT
Cordeiro 2015	Not RCT
de Los Santos 2015	Ovum donation ‐ Not RCT
Drabkova 2016	Not RCT
Fu 2013	Not RCT
Garip 2016	Not true RCT
Gonsalvez‐Alvarez 2015	Not RCT – Ovum donation
Hardarson 2008	Not RCT
Kato 2007	Not RCT
Kirkegaard 2013	Comparison of variation in metabolome according to clinical outcome ‐ Not RCT
Kirkegaard 2014	Not RCT
Li 2015	Not RCT
Lian 2010	No review outcome of interest was measured; metabolomic assessment of follicular fluid in both groups was compared
McRae 2012	No review outcome of interest was measured; metabolomic assessment of follicular fluid before oocyte retrieval was compared in both groups
Montani 2016	Not RCT
Montsko 2015	No review outcome of interest was measured ‐ Not RCT
Nagy 2015	Not RCT
NCT01427413	Not RCT
Rødgaard 2015	Not RCT
Scott 2008	Matched controls ‐ Not RCT
Seli 2007	Not RCT
Seli 2010	Not RCT
Simerman 2015	Not RCT
Valckx 2014	No outcome of interest ‐ Not RCT
Vergouw 2008	Not RCT
Xia 2014	No outcome of interest‐ Not RCT
Yildizfer 2015	Not RCT
Zhao 2013	Not RCT