Study	Reason for exclusion
Benedict 2010	Not an RCT.
Biton 2005	Ineligible population (people with primary generalised tonic‐clonic).
Critchley 2005	Ineligible population (healthy people).
Kim 2012	Not an RCT.
Kluger 2007	Not an RCT.
Knupp 2016	Not an RCT.
Lesser 2005	No rufinamide in add‐on.
Madeddu 2013	Ineligible population (people with epileptic encephalopathies secondary to complex brain malformations).
Palhagen 2001	Ineligible population (participants with no refractory epilepsy).
Racine 2000	Conference (4th European Congress on Epileptology): abstract and full paper not available.
Todorov 2005	No rufinamide in add‐on.
Xu 2016	Ineligible population (healthy people).

RCT: randomised controlled trial;