Cocchi 1997.

Methods	Randomized comparative trial
Participants	122 depressed people with alcohol dependence (95 men and 27 women; mean age: 42 years) Inclusion criteria: DSM‐IV diagnosis F10‐24 ZUNG score > 49 Exclusion criteria: information not available Participants with bipolar disorder: information not available
Interventions	Drugs: paroxetine (20 mg/day; 61 participants; 49 men and 12 women; age (mean ± SD) = 42.1 ± 11.5 years) amitriptyline (25 mg/day; 61 participants; 46 men and 15 women; age (mean ± SD) = 42.2 ± 10.7 years) Psychotherapy: information not available Scheduled duration of treatment: 3‐4 weeks Site: Alcohol Unit, casa di Cura Villa Silvia per malattie nervose e mentali, Senigallia, Italy Setting: inpatients Route of administration: orally Starting dose: information not available Pattern of dose reduction: information not available
Outcomes	Depression final ZUNG score response (according to ZUNG) remission (according to ZUNG) Alcohol dependence: data not available Dropouts: data not available Adverse effects: data not available
Notes	Baseline characteristics of participants Depression: primary depression: information not available duration: information not available ZUNG score (mean ± SD): paroxetine = 68.8 ± 9.0; amitriptyline = 63.3 ± 6.0 Alcohol dependence: data not available Other psychiatric comorbidity: information not available Other substance use disorders: information not available Other characteristics of study Other pharmacological treatment: information not available Funding sources: information not available Declaration of interest: information not available Other information Data on response and remission were excluded because evaluated using a self‐administered scale.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Random allocation stated. No further details provided.
Allocation concealment (selection bias)	Unclear risk	Method of concealment not described.
Blinding of participants and personnel (performance bias) All outcomes	High risk	No information on the design (double‐blind or open trial), on the preparation and appearance of medications, and on blinding of participants and personnel.
Blinding of outcome assessment (detection bias) objective	Low risk	No information on study design (double‐blind or open trial).
Blinding of outcome assessment (detection bias) subjective	High risk	No information on study design (double‐blind or open trial).
Incomplete outcome data (attrition bias) All outcomes	High risk	Methods applied to account for missing data. Intention‐to‐treat approach not reported. No high number of dropouts or unbalanced between groups.
Selective reporting (reporting bias)	Unclear risk	Information insufficient to permit judgement.