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. 2018 Oct 3;24(3):431–446. doi: 10.1038/s41380-018-0255-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — RNA sequencing and differentially expressed genes (DEGs) in mice. The absence of TYROBP downregulated half of the genes upregulated in APP/PSEN1 mice vs. WT. RNA sequencing was performed on the prefrontal cortex for six groups of mice at 8-month -old of age (WT (n = 4), Tyrobp^+/− (n = 3), Tyrobp^−/− (n = 4), APP/PSEN1 (n = 4), APP/PSEN1;Tyrobp^+/− (n = 4), and APP/PSEN1;Tyrobp^−/− (n = 5)). a Volcano plot representations of the DEGs in WT and APP/PSEN1 mice heterozygous, knockout or WT for Tyrobp. Red dots represent DEGs at an FDR of 0.05. b Comparison of the shared and unique DEGs (FDR < 0.05) in APP/PSEN1, APP/PSEN1;Tyrobp^−/− and Tyrobp^−/− mice. The bar height denotes the number of DEGs overlapping in a given comparison as specified by the green circles underneath. The p value denotes the significance of the overlap size. List of overlapping DEGs are shown above the bars except for the comparison between APP/PSEN1;Tyrobp^−/− vs. APP/PSEN1 (Dn) and APP/PSEN1;Tyrobp^−/− vs. WT (see Suppl. Figure 3c). Up upregulated; Dn downregulated genes