Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 3;24(3):431–446. doi: 10.1038/s41380-018-0255-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — Gene set enrichment analysis on the DEGs of Tyrobp^−/−, APP/PSEN1;Tyrobp^−/− and APP/PSEN1 mice at 8-months old using ingenuity pathway analysis (IPA). The absence of TYROBP in APP/PSEN1 mice alleviated the induction of the immune/pro-inflammatory response observed in the APP/PSEN1 mouse brain. a Heatmap of selected dysregulated canonical pathways in APP/PSEN1, APP/PSEN1;Tyrobp^−/−, and Tyrobp^−/− mice and in the different comparisons. Data presented as −log(FDR). Pathways were selected for known or suspected relevance to AD pathophysiology. Full results of canonical pathway analyses are presented in Suppl. Table 2. b Heatmap of significantly affected genes in selected affected canonical pathways. Data presented as −log2 (fold change). Full results are presented in Suppl. Table 2. c Heatmap of predicted activated or inhibited canonical pathways in APP/PSEN1, APP/PSEN1;Tyrobp^−/− and Tyrobp^−/− mice and in the different comparisons. Data presented as z-score