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. 2018 Oct 3;24(3):431–446. doi: 10.1038/s41380-018-0255-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — An immune/microglia enriched gene network regulated by TYROBP. The Bayesian causal network, comprised of the three-layer neighborhoods of TYROBP (716 genes), was significantly enriched (10.3-fold, FET p value 2.7 × 10⁻⁵¹) for the genes downregulated (blue color) by Tyrobp knockout in APP/PSEN1 mice. Diamond shape denotes AD GWAS hits