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. 2018 Oct 3;24(3):431–446. doi: 10.1038/s41380-018-0255-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Absence of TYROBP does not modify the percentage of 6E10 immunoreactive Aß deposits nor the total number of microglia in 8-month -old APP/PSEN1 mice. a, b Images of 6E10-immunoreactive plaques (red) and anti Iba1-immunostained microglia (green) in PFCs (a) and hippocampi (HC) (b) of APP/PSEN1 and APP/PSEN1;Tyrobp^−/− mice. c Percentage of 6E10-immunoreactive area in PFC and hippocampi of male and female APP/PSEN1 (n = 7–8), and APP/PSEN1;Tyrobp^−/− (n = 7–8) mice. Sex effect: ns. d Quantification of the number of Iba1-immunostained microglia in cortices and hippocampi of male and female APP/PSEN1 (n = 8) and APP/PSEN1;Tyrobp^−/− (n = 8) mice. Sex effect: ns. Mann–Whitney test was for statistical comparisons. ns not significant. Data presented as mean ± SEM