Table 3:

Univariate and multivariate proportional hazards regression analysis.

	Univariate analysis			Multivariate analysis¹

	Hazard Ratio	95% CI	p-value	Hazard Ratio	95% CI	p-value
Age > 65 years	1.39	0.53–3.70	0.50
Gender (male)	1.02	0.38–3.21	0.97
Hepatitis B +	0.98	0.28–2.77	0.98
Hepatitis C +	0.65	0.22–1.71	0.39
Edmondson-Steiner Grade (1,2 vs. 3,4)	1.10	0.42–2.93	0.85
Serum alpha-fetoprotein > 400 ng/mL	2.43	0.83–6.45	0.10

Tumor Size > 4cm	3.8	1.34–13.5	0.01	4.7	1.50–18.4	<0.01

PET Phenotype (FCh_HIGH vs. FCh_LOW)	0.36	0.14–0.95	0.04	0.13	0.03–0.58	<0.01
Hoshida signature² (S3 vs. S1-S2)	0.33	0.12–0.88	0.03	0.43	0.15–1.26	0.13
Lee signature³ (good vs. poor survival)	0.36	0.11–0.93	0.04	0.46	0.15–1.35	0.16
Villanueva signature⁴ (good vs. poor survival)	0.23	0.07–0.64	0.01	0.30	0.09–0.87	0.03

adjusted for age, gender, and tumor size.

From Hoshida et al. (2009).

From Lee et al. (2004). Limited to 35 patients confidently classified by this signature.

⁴

From Villanueva et al (2011). Limited to 35 patients confidently classified by this signature.