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. Author manuscript; available in PMC: 2020 Feb 26.
Published in final edited form as: ACS Nano. 2019 Feb 8;13(2):2398–2409. doi: 10.1021/acsnano.8b09266

Figure 6: Electro-mechanical modulation of FraC conductance.

Figure 6:

(a) Schematic of the single-peptide capture and stretching. Level 1 represents the open pore current. Level 2 represents the peptide captured at low voltages (−30 mV). Level 3, 4 and 5 represent peptide stretching at −50, −70 and −90 mV consecutively. (b) Current trace corresponding to the capture and stretching of a single peptide. The very first part of the recording shows capture of the FraC nanopore. (c) Current traces of individual peptides being stretched (top), or stretched and consequently compressed (bottom). (d) Example histogram of the current values corresponding to stretching a single peptide within FraC nanopore by −50, −70 and −90 mV voltages (top). Histogram of current blockade values obtained from multiple measurements of multiple peptides, each carried out at one of the following fixed value of the applied voltage: −50, −70, and −90 mV (bottom).