Comparison 4. Subgroup analysis 3: type of alpha‐blocker.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Stone clearance	67	10897	Risk Ratio (M‐H, Random, 95% CI)	1.49 [1.39, 1.58]
1.1 Tamsulosin	54	8896	Risk Ratio (M‐H, Random, 95% CI)	1.47 [1.37, 1.59]
1.2 Alfuzosin	6	391	Risk Ratio (M‐H, Random, 95% CI)	1.51 [1.14, 2.01]
1.3 Doxazosin	7	441	Risk Ratio (M‐H, Random, 95% CI)	1.49 [1.29, 1.72]
1.4 Terazosin	2	119	Risk Ratio (M‐H, Random, 95% CI)	1.44 [1.10, 1.89]
1.5 Naftopidil	3	270	Risk Ratio (M‐H, Random, 95% CI)	2.02 [1.01, 4.03]
1.6 Silodosin	6	780	Risk Ratio (M‐H, Random, 95% CI)	1.39 [1.20, 1.61]
2 Major adverse events	18	3003	Risk Ratio (M‐H, Random, 95% CI)	1.98 [1.12, 3.48]
2.1 Tamsulosin	13	2062	Risk Ratio (M‐H, Random, 95% CI)	1.24 [0.62, 2.47]
2.2 Alfuzosin	5	323	Risk Ratio (M‐H, Random, 95% CI)	5.51 [1.46, 20.83]
2.3 Doxazosin	2	133	Risk Ratio (M‐H, Random, 95% CI)	3.84 [0.47, 31.11]
2.4 Silodosin	3	361	Risk Ratio (M‐H, Random, 95% CI)	6.25 [0.74, 52.57]
2.5 Naftopidil	1	124	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
3 Stone expulsion time	35	6212	Mean Difference (IV, Random, 95% CI)	‐3.56 [‐4.25, ‐2.87]
3.1 Tamsulosin	30	5052	Mean Difference (IV, Random, 95% CI)	‐3.07 [‐4.04, ‐2.09]
3.2 Alfuzosin	3	180	Mean Difference (IV, Random, 95% CI)	‐4.75 [‐6.63, ‐2.88]
3.3 Doxazosin	4	263	Mean Difference (IV, Random, 95% CI)	‐4.73 [‐6.15, ‐3.32]
3.4 Terazosin	2	119	Mean Difference (IV, Random, 95% CI)	‐4.42 [‐5.36, ‐3.48]
3.5 Naftopidil	1	86	Mean Difference (IV, Random, 95% CI)	‐1.80 [‐2.80, ‐0.80]
3.6 Silodosin	4	512	Mean Difference (IV, Random, 95% CI)	‐4.98 [‐6.43, ‐3.52]
4 Pain episodes	15	1595	Mean Difference (IV, Random, 95% CI)	‐0.71 [‐0.89, ‐0.52]
4.1 Tamsulosin	13	992	Mean Difference (IV, Random, 95% CI)	‐0.69 [‐0.98, ‐0.41]
4.2 Alfuzosin	1	58	Mean Difference (IV, Random, 95% CI)	‐0.32 [‐0.82, 0.18]
4.3 Doxazosin	3	190	Mean Difference (IV, Random, 95% CI)	‐0.76 [‐0.92, ‐0.60]
4.4 Terazosin	2	119	Mean Difference (IV, Random, 95% CI)	‐0.67 [‐1.16, ‐0.17]
4.5 Naftopidil	1	86	Mean Difference (IV, Random, 95% CI)	‐0.80 [‐1.23, ‐0.37]
4.6 Silodosin	2	150	Mean Difference (IV, Random, 95% CI)	‐0.89 [‐2.05, 0.26]
5 Dose of diclofenac [mg]	14	4429	Mean Difference (IV, Random, 95% CI)	‐78.11 [‐113.25, ‐42.97]
5.1 Tamsulosin	12	4135	Mean Difference (IV, Random, 95% CI)	‐87.60 [‐131.98, ‐43.21]
5.2 Doxazosin	1	57	Mean Difference (IV, Random, 95% CI)	‐63.46 [‐72.88, ‐54.04]
5.3 Terazosin	1	56	Mean Difference (IV, Random, 95% CI)	‐64.29 [‐74.17, ‐54.41]
5.4 Silodosin	2	181	Mean Difference (IV, Random, 95% CI)	‐54.72 [‐89.91, ‐19.53]
6 Hospitalisation	13	2028	Risk Ratio (M‐H, Random, 95% CI)	0.44 [0.29, 0.66]
6.1 Tamsulosin	11	1606	Risk Ratio (M‐H, Random, 95% CI)	0.57 [0.38, 0.86]
6.2 Alfuzosin	2	110	Risk Ratio (M‐H, Random, 95% CI)	0.35 [0.09, 1.45]
6.3 Doxazosin	2	132	Risk Ratio (M‐H, Random, 95% CI)	0.19 [0.01, 3.05]
6.4 Silodosin	2	180	Risk Ratio (M‐H, Random, 95% CI)	0.26 [0.12, 0.55]
7 Surgical intervention	19	3404	Risk Ratio (M‐H, Random, 95% CI)	0.74 [0.55, 0.99]
7.1 Tamsulosin	16	2820	Risk Ratio (M‐H, Random, 95% CI)	0.82 [0.59, 1.13]
7.2 Alfuzosin	1	58	Risk Ratio (M‐H, Random, 95% CI)	0.47 [0.09, 2.35]
7.3 Doxazosin	2	133	Risk Ratio (M‐H, Random, 95% CI)	0.41 [0.15, 1.11]
7.4 Silodosin	3	393	Risk Ratio (M‐H, Random, 95% CI)	0.29 [0.06, 1.31]