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. 2018 May 12;2018(5):CD012540. doi: 10.1002/14651858.CD012540.pub2

2. Definition of remission by study.

Study Length of remission prior to drug withdrawal Definition of remission prior to drug withdrawal
Roblin 2017 Minimum 6 months CDAI ≤ 150 and fecal calprotectin levels < 250 μg/g
Lémann 2005 Mean 62 months (standard deviation 26 months); Minimum 42 months Clinical remission (CDAI ≤ 150) and no need for medical/surgical therapy in the previous 42 months
O'Donoghue 1978 Minimum 6 months Clinical remission not otherwise specified
Van Assche 2008 Minimum 6 months Clinical response to infliximab and disease control
Vilien 2004 Not specified Clinical remission: physician's global assessment
Wenzl 2015 Minimum 12 months Clinical remission, no need for new medical therapy in the previous 12 months