Comparison 3. Mineral trioxide aggregate (MTA) pulpotomy versus 1:5 diluted formocresol pulpotomy.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Clinical failure	8		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 6 months	8	560	Risk Ratio (M‐H, Fixed, 95% CI)	0.16 [0.01, 3.06]
1.2 12 months	7	308	Risk Ratio (M‐H, Fixed, 95% CI)	0.16 [0.02, 1.28]
1.3 24 months	6	258	Risk Ratio (M‐H, Fixed, 95% CI)	0.51 [0.18, 1.42]
2 Radiological failure	8		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 6 months	8	560	Risk Ratio (M‐H, Fixed, 95% CI)	0.41 [0.17, 1.03]
2.2 12 months	7	308	Risk Ratio (M‐H, Fixed, 95% CI)	0.56 [0.20, 1.53]
2.3 24 months	6	258	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.31, 1.46]
3 Pain	4		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 6 months	4	200	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.2 12 months	3	150	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.3 24 months	2	100	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.13, 70.30]
4 Soft tissue pathology	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 6 months	5	220	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
4.2 12 months	4	170	Risk Ratio (M‐H, Fixed, 95% CI)	0.2 [0.02, 1.65]
4.3 24 months	3	120	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.01, 7.72]
5 Pathological mobility	4		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 6 months	4	180	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
5.2 12 months	3	130	Risk Ratio (M‐H, Fixed, 95% CI)	0.2 [0.01, 3.97]
5.3 24 months	2	80	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
6 Pathological radiolucency	9		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 6 months	9	622	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.30, 1.27]
6.2 12 months	7	320	Risk Ratio (M‐H, Fixed, 95% CI)	0.36 [0.13, 1.02]
6.3 24 months	6	270	Risk Ratio (M‐H, Fixed, 95% CI)	0.6 [0.23, 1.57]
7 Pathological root resorption	8		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
7.1 6 months	8	550	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.24, 1.99]
7.2 12 months	6	248	Risk Ratio (M‐H, Fixed, 95% CI)	0.25 [0.05, 1.14]
7.3 24 months	4	148	Risk Ratio (M‐H, Fixed, 95% CI)	0.43 [0.10, 1.92]
8 Pulp canal obliteration	7		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
8.1 6 months	7	520	Risk Ratio (M‐H, Fixed, 95% CI)	1.52 [1.00, 2.30]
8.2 12 months	5	218	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.44, 2.26]
8.3 24 months	5	218	Risk Ratio (M‐H, Fixed, 95% CI)	1.97 [0.99, 3.89]