Lourenço 2015a.

Methods	RCT, parallel arm Teeth randomly assigned Setting and operators not mentioned
Participants	22 children, 30 teeth, mean age 6.6 years, standard deviation age 1.4 years.
Interventions	Group 1:Pulpotomy (Portland cement, PC); n = 10 (1 visit) Rubber dam Caries removal prior to pulpal access Pulp access with high‐speed and round carbide bur Pulpotomy amputation with excavator Irrigation with saline For haemostasis, dry sterile cotton pellet PC applied after pulpotomy, followed by IRM before being restored with resin glass ionomer Group 2:Pulpotomy (PC + iodoform, PC + CHI₃); n = 10 (1 visit) Rubber dam Caries removal prior to pulpal access Pulp access with high‐speed and round carbide bur Pulpotomy amputation with excavator Irrigation with saline For haemostasis, dry sterile cotton pellet PC + CHI₃ (20% radiopacifier, 80% PC) applied after pulpotomy, followed by IRM before being restored with resin glass ionomer Group 3:Pulpotomy (PC + zirconium oxide, PC + ZrO₂); n = 10 (1 visit) Rubber dam Caries removal prior to pulpal access Pulp access with high‐speed and round carbide bur Pulpotomy amputation with excavator Irrigation with saline For haemostasis, dry sterile cotton pellet PC + ZrO₂ (20% radiopacifier, 80% PC) applied after pulpotomy, followed by IRM before being restored with resin glass ionomer
Outcomes	Clinical success (no swelling, fistula, spontaneous pain, mobility), radiological success (no furcation radiolucency, internal root resorption, external root resorption): evaluation at 6, 12 and 24 months (at tooth level)
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computerised random‐number generator
Allocation concealment (selection bias)	Unclear risk	Insufficient information to make a clear judgement
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to make a clear judgement
Blinding of clinical outcomes assessment	Low risk	Quote: "...at each follow‐up examination two investigators who were blinded to the identification of the medicaments ... performed clinical... examination of the pulpotomized teeth"
Blinding of radiological outcomes assessment	Low risk	quote: "...at each follow‐up examination two investigators who were blinded to the identification of the medicaments ... performed... periapical examination of the pulpotomized teeth"
Incomplete outcome data (attrition bias) All outcomes	Low risk	Proportion of missing outcomes < 10% of children randomly assigned
Selective reporting (reporting bias)	Unclear risk	Insufficient information to make a clear judgement