Nakornchai 2010.

Methods	RCT, parallel‐arm Teeth randomly assigned Setting not mentioned. Conducted in Thailand. 1 operator not mentioned
Participants	37 children, 50 teeth, age range 3 to 8 years
Interventions	Group 1:Pulpectomy (ciprofloxacin + metronidazole + minocycline); n = 25 (1 visit) Rubber dam Caries removal prior to pulpal access not mentioned Pulp access with high‐speed bur Pulpotomy amputation with excavator For haemostasis, cotton pellets moistened with 10% sodium hypochlorite maintained for 1 minute Irrigation with 2.5% sodium hypochlorite The cavity was then dried with cotton pellets. 3Mix (ciprofloxacin + metronidazole + minocycline) applied after pulpectomy, followed by IRM dressing before glass ionomer cement and stainless‐steel crown Group 2:Pulpectomy (calcium hydroxide + iodoform); n = 25 (1 or 2 visits) Rubber dam Caries removal prior to pulpal access not mentioned Pulp access not mentioned Pulpotomy amputation with excavator No haemostasis Irrigation with 2.5% sodium hypochlorite Instrumentation with barbed broaches The canals were dried with sterile paper points. Vitapex (CH/iodoform) applied after pulpectomy, followed by IRM dressing before glass ionomer cement A single visit root canal procedure was undertaken in 14 of the 25 teeth. The remaining teeth were treated in 2 visits due to great deal of gingival swelling and discharge
Outcomes	Clinical success (pain, gingival abscesses, fistula openings or abnormal mobility), radiological success (static or reduced size of bifurcation/periapical radiolucency, no progression of pathological external root resorption, no progression of internal root resorption and no newly formed radiographic lesions), spontaneous pain, tenderness to percussion, swelling, fistula, pathological mobility, abscess, furcal radiolucency, periapical radiolucency, internal root resorption, external root resorption, calcific metamorphosis: evaluation at 9 and 12 months (at tooth level)
Notes	Source of funding: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Coin toss
Allocation concealment (selection bias)	Unclear risk	Insufficient information to make a clear judgement
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to make a clear judgement
Blinding of clinical outcomes assessment	Low risk	Blinded clinical evaluations were performed by the operator
Blinding of radiological outcomes assessment	Unclear risk	Insufficient information to make a clear judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing data
Selective reporting (reporting bias)	Unclear risk	Insufficient information to make a clear judgement