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. 2018 May 31;2018(5):CD003220. doi: 10.1002/14651858.CD003220.pub3

Noorollahian 2008.

Methods RCT, parallel‐arm
Teeth randomly assigned
Conducted in the Paediatric Dentistry Department, Faculty of Dentistry, Zahedan University of Medical Sciences, Iran. Operators not mentioned
Participants 46 children, 60 teeth, mean age 6.1 years, age range 5 to 7 years
Interventions Group 1:Pulpotomy (formocresol); n = 30 (1 visit)
  • Rubber dam

  • Caries removal prior to pulpal access not mentioned

  • Pulp access with high‐speed bur

  • Pulpotomy amputation not mentioned

  • For haemostasis, no precision

  • No irrigation

  • Cotton wool pellet soaked with FC placed on pulp stumps for 5 minutes after pulpotomy, followed by ZOE before being restored with stainless‐steel crown


Group 2:Pulpotomy (MTA); n = 30 (2 visits)
  • Rubber dam

  • Caries removal prior to pulpal access not mentioned

  • Pulp access with high‐speed bur

  • Pulpotomy amputation not mentioned

  • For haemostasis, no precision

  • No irrigation

  • MTA (3:1 powder:water ratio) applied after pulpotomy. A cotton pellet moistened with normal saline was placed over the MTA paste and the tooth was temporarily restored using ZOE. Then ZOE before being restored with stainless‐steel crown after 24 hours

Outcomes Clinical success (no pain symptoms, no tenderness of percussion, no swelling, no fistulation or no pathological mobility), radiological success (no evidence of radicular radiolucency, no internal or external root resorption or no periodontal ligament space widening), signs of failure (internal root resorption, furcation radiolucency, periapical bone destruction, pain, swelling or sinus tract), furcation involvement, pulp canal obliteration: evaluation at 6, 12 and 24 months (at tooth level)
Notes Dropouts: at 24 months "12 out of 30 teeth in the two groups", no reasons stated
Source of funding: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Random number table
Allocation concealment (selection bias) Unclear risk Insufficient information to make a clear judgement
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Insufficient information to make a clear judgement
Blinding of clinical outcomes assessment Low risk Quote: "...the children were examined clinically by the author who was blind to which treatment group the subject belonged"
Blinding of radiological outcomes assessment Low risk Quote: "...the children were examined radiographically by the author who was blind to which treatment group the subject belonged"
Incomplete outcome data (attrition bias) 
 All outcomes High risk Proportion of missing outcomes > 10% children randomly assigned
Selective reporting (reporting bias) Unclear risk Insufficient information to make a clear judgement