Pinky 2011.
| Methods | RCT, parallel‐arm Teeth randomly assigned Conducted in the Outpatient Department of Pedodontics and Preventive Dentistry, College of Dental Sciences, Davangere, India. Operators not mentioned |
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| Participants | 28 children, 40 teeth, age range 4 to 10 years | |
| Interventions |
Group 1:Pulpectomy (ciprofloxacin + metronidazole + minocycline); n = 20 (3 visits)
3Mix (ciprofloxacin + metronidazole + minocycline) after pulpectomy. Commercially available chemotherapeutic agents such as ciprofloxacin, metronidazole and minocycline, were used. After removal of enteric coating, these drugs were pulverised using sterile porcelain mortar and pestle. These powdered drugs were mixed into 2 different combinations in the ratio of 1:3:3, i.e. 1 group being 1 part of ciprofloxacin, 3 parts of metronidazole and 3 parts of minocycline, kept separately to prevent exposure to light and moisture. 1 increment of each powdered drug was mixed with propylene glycol to form an ointment just before use. Canal orifices were enlarged to receive medicament termed as "medication cavity". This was accomplished using a round bur, following which cavities were cleaned and irrigated with the help of saline and dried. The medication cavities were filled with 1 of the pastes and given a temporary dressing with ZOE. Children were recalled after 15 days for resolution of clinical signs and symptoms, following which permanent restoration was done with glass‐ionomer cement. At 30 days, following successful treatment, stainless‐steel crowns were placed and x‐rays taken Group 2:Pulpectomy (ciprofloxacin + ornidazole + minocycline); n = 20 (3 visits)
Ciprofloxacin + ornidazole + minocycline after pulpectomy. Commercially available chemotherapeutic agents such as ciprofloxacin, minocycline and ornidazole were used. After removal of enteric coating, these drugs were pulverised using sterile porcelain mortar and pestle. These powdered drugs were mixed into 2 different combinations in the ratio of 1:3:3, i.e. 1 group being 1 part of ciprofloxacin with 3 parts of ornidazole and 3 parts of minocycline, kept separately to prevent exposure to light and moisture. 1 increment of each powdered drug was mixed with propylene glycol to form an ointment just before use. Canal orifices were enlarged to receive medicament termed as "medication cavity". This was accomplished using a round bur, following which cavities were cleaned and irrigated with the help of saline and dried. The medication cavities were filled with 1 of the pastes and given a temporary dressing with ZOE. Children were recalled after 15 days for resolution of clinical signs and symptoms, following which permanent restoration was done with glass‐ionomer cement. At 30 days, following successful treatment, stainless‐steel crowns were placed and x‐rays taken |
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| Outcomes | Clinical success (absence of spontaneous pain, tenderness to percussion, abnormal mobility and signs of pathology such as intraoral or extraoral abscess), pain symptoms, tenderness to percussion, abscess: evaluation at 3, 6 and 12 months (at tooth level) Radiological success (radiolucency decreased compared with preoperative status or remained same), furcal radiolucency: evaluation at 6 and 12 months (at tooth level) |
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| Notes | Source of funding: not reported | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Insufficient information to make a clear judgement |
| Allocation concealment (selection bias) | Unclear risk | Insufficient information to make a clear judgement |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Insufficient information to make a clear judgement |
| Blinding of clinical outcomes assessment | Unclear risk | Insufficient information to make a clear judgement |
| Blinding of radiological outcomes assessment | Unclear risk | Insufficient information to make a clear judgement |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | No missing data |
| Selective reporting (reporting bias) | Unclear risk | Insufficient information to make a clear judgement |