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. 2018 May 31;2018(5):CD003220. doi: 10.1002/14651858.CD003220.pub3

Subramaniam 2009.

Methods RCT, split‐mouth
Teeth randomly assigned
Conducted in the Department of Pedodontics and Preventive Dentistry, The Oxford Dental College, Hospital and Research Center, Bangalore, India. Operators not mentioned
Participants 19 children, 40 teeth, age range 6 to 8 years
Interventions Group 1:Pulpotomy (formocresol); n = 20 (2 visits)
  • Rubber dam

  • Caries removal prior to pulpal access

  • Pulp access with high‐speed bur

  • Pulpotomy amputation with excavator

  • For haemostasis, moistened cotton pellet with water

  • No irrigation

  • Cotton wool pellet soaked with FC placed on pulp stumps for 1 minute after pulpotomy, followed by ZOE before being restored with glass‐ionomer cement and stainless‐steel crown 1 week after


Group 2:Pulpotomy (MTA); n = 20 (2 visits)
  • Rubber dam

  • Caries removal prior to pulpal access

  • Pulp access with high‐speed bur

  • Pulpotomy amputation with excavator

  • For haemostasis, moistened cotton pellet with water

  • No irrigation

  • MTA (3:1 powder:saline ratio) applied after pulpotomy, followed by ZOE before being restored with glass‐ionomer cement and stainless‐steel crown 1 week after

Outcomes Clinical success (no history of pain, no tenderness to percussion, no gingival abscess, no sinus/fistula and no pathological mobility), radiographic success (no internal/external root resorption or no periapical/furcal radiolucency), signs of success (no history of pain, no tenderness to percussion, no gingival abscess, no sinus/fistula and no pathological mobility, no internal/external root resorption or no periapical/furcal radiolucency), furcal radiolucency, pulp canal obliteration, dentine bridge formation: evaluation at 1, 6, 12 and 24 months (at tooth level)
Notes Source of funding: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Coin toss
Allocation concealment (selection bias) Unclear risk Insufficient information to make a clear judgement
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Insufficient information to make a clear judgement
Blinding of clinical outcomes assessment Unclear risk Insufficient information to make a clear judgement
Blinding of radiological outcomes assessment Unclear risk Insufficient information to make a clear judgement
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No missing data
Selective reporting (reporting bias) Unclear risk Insufficient information to make a clear judgement