| 1 Lung function (spirometry indices) |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.1 FEV1 (in L, end study minus baseline values) |
2 |
156 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.09 [‐0.26, 0.09] |
| 1.2 FVC (in L, end study minus baseline values) |
2 |
156 |
Mean Difference (IV, Fixed, 95% CI) |
0.01 [‐0.16, 0.17] |
| 2 Lung function (other indices) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 2.1 Diffusion capacity % predicted (end of study) |
1 |
57 |
Mean Difference (IV, Fixed, 95% CI) |
2.70 [‐2.49, 7.89] |
| 2.2 RV % predicted (end of study values) |
1 |
57 |
Mean Difference (IV, Fixed, 95% CI) |
2.0 [‐9.41, 13.41] |
| 2.3 TLC % predicted (end of study values) |
1 |
57 |
Mean Difference (IV, Fixed, 95% CI) |
3.20 [‐1.99, 8.39] |
| 3 Clinical severity indices |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 3.1 Number of participants with regular wheeze (combined) |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 3.2 Number of participants without sputum reduction of > 50% (combined) |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 3.3 Number of participants with no improvement in dyspnoea score > 1 (min important difference) (1000F) |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 3.4 Number of participants with no clinically significant improvement in HRQoL |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 4 Exacerbations |
2 |
127 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.17 [‐0.56, 0.22] |
| 4.1 Average number of exacerbations per participant |
2 |
127 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.17 [‐0.56, 0.22] |
| 5 Sputum and biomarkers characteristics |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 5.1 Sputum volume or weight (per day) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 6 Pseudomonas aeruginosa colonisation |
2 |
156 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.94 [0.45, 1.96] |
| 7 St George HRQoL (end of study minus baseline) |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 7.1 Total score |
2 |
127 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.54 [‐8.00, 0.92] |
| 7.2 Symptom score |
2 |
127 |
Mean Difference (IV, Fixed, 95% CI) |
‐4.75 [‐10.42, 0.92] |
| 7.3 Activity score |
2 |
127 |
Mean Difference (IV, Fixed, 95% CI) |
‐6.21 [‐12.40, ‐0.01] |
| 7.4 Impact score |
1 |
70 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.63 [‐9.35, 2.09] |
