Study ID	Treatment	General	Nausea ± vomiting	Local reaction	Pain/stiffness/ tightness	Temperature sensation	Feeling of heaviness	Dizziness	Somnolence
Bahra 2000	(1) Zolmitriptan 5 mg oral, n = 114 (2) Zolmitriptan 10 mg oral, n = 111 (3) Placebo, n = 115	Detailed list (ITT pop not safety pop) for pts with specific events occurring in > 2%, and all chest symptoms	(1) 6/114 (2) 4/111 (3) 2/115	Paresthesia (NB oral route): (1) 3/114 (2) 11/111 (3) 7/115 Most common AE	Pain: (1) 2/114 (2) 6/111 (3) 4/115 Tightness: (1) 3/114 (2) 4/111 (3) 2/115	Sweating: (1) 0/114 (2) 4/111 (3) 0/115	(1) 3/114 (2) 6/111 (3) 0/115	(1) 4/114 (2) 4/111 (3) 1/115	(1) 4/114 (2) 3/111 (3) 2/115
Cittadini 2006	(1) Zolmitriptan 5 mg IN, n = 65 (2) Zolmitriptan 10 mg IN, n = 63 (3) Placebo, n = 61	No  details of specific AEs
Ekbom 1991	(1) Sumatriptan 6 mg SC, n = 39 (2) Placebo, n = 39 Not self‐administered (phys/nurse)	Primarily two types: 1. injection site reactions (pain, swelling, burning, erythema, tingling) 11/39, 7/39 2. neurologic symptoms(dizziness, tiredness, numbness of hands, tingling, paraesthesia, feeling of paralysis of face, cold and hot sensations) 12/39, 8/39
Ekbom 1993	(1) Sumatriptan 6 mg SC, n = 92 (2) Sumatriptan 12 mg SC, n = 88 (3) Placebo, n = 88 Not self‐administered (phys/nurse)	14 events of severe intensity (injection site reaction, flushing, sweating, warm sensation, malaise/fatigue, prickling sensation) Chest symptoms mild or moderate, resolve ≥ 30 min (pressure 2 suma 6 mg, tightness 1 suma 6 mg and 1 suma 12 mg) AEs in ≥ 5% of participants	(1) 5/101 (2) 6/94 (3) 1/96	Injection site reaction: (1) 7/101 (2) 9/94 (3 4/96	(1) 1/101 (2) 5/94 (3) 0/96	(1) 5/101 (2) 3/94 (3) 1/96	(1) 5/101 (2) 5/94 (3) 1/96
Rapoport 2007	(1) Zolmitriptan 5 mg IN, n = 52 (2) Zolmitriptan 10 mg IN, n = 49 (3) Placebo, n = 50	Mild, nonspecific, typical of triptan sensations	(1) 0/52 (2) 2/49 (3) 0/50	Bad taste: (1) 8/52 (2) 11/49 (3) 5/50 Discomfort of nasal cavity: (1) 4/52 (2) 6/49 (3) 3/50	Throat: (1) 1/52 (2) 2/49 (3) 1/50 Chest: (1) 1/52 (2) 1/49 (3) 0/50 Neck: (1) 2/52 (2) 2/49 (3) 0/50			(1) 2/52 (2) 2/49 (3) 1/50	(1) 3/52 (2) 4/49 (3) 2/50
Van Vliet 2003	(1) Sumatriptan 20 mg IN, n = 77 (2) Placebo, n = 77	Very limited data		Bitter taste: (1) 21% (2) 1% (most common event)	Chest pressure: (1) 2/77 (2) 0/77
IN ‐ intranasal; n ‐ number of participants; pts ‐ participants; SC ‐ subcutaneous