Aglamis 2008

Methods	Randomised controlled trial.
Participants	Inclusion criteria: OA of knee meeting ACR radiographic grade II, III or IV criteria; aged 50‐69 years; judged to be engaged in independent in daily activity. Exclusion criteria: use of intra‐articular injections in the last 6 months; involved in regular physical activity and physiotherapy, using assistive equipment, unable to exercise, diagnosed with a chronic condition, or a combination of these. Country: Turkey. Sample number: IG: 16; CG: 9. Mean age: 57 years. 100% women.
Interventions	Provider(s): fitness trainer and health technician. Training: yes. Setting: not stated. Content: multicomponent: strength/resistance + aerobic + patient information. Length/intensity: 3 sessions a week for 12 weeks. Control: waiting list.
Outcomes	At 12 weeks: pain (WOMAC); function (WOMAC); SF‐36: Mental health; social function; emotional role, vitality.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random numbers table.
Allocation concealment (selection bias)	Low risk	Managed externally to the project.
Blinding of participants and personnel (performance bias) All outcomes	High risk	Not reported. However, participants and providers unlikely to be blinded to exercise intervention.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Blinding of outcome assessments.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Attrition: IG: 5.8% (1/17); CG: 35.7% (5/14). Lost to follow‐up: IG: 1 reactive arthritis; CG: 2 change of city; 1 low back pain; 1 intra‐articular injection; 1 no contact. ITT/intervention received not reported. Note that there was a higher rate of attrition in the CG, increasing risk, and that some instances may relate to lack of intervention.
Selective reporting (reporting bias)	Low risk	All outcomes reported.
Other bias	Low risk	No other bias detected.