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. 2018 Apr 15;2018(4):CD000249. doi: 10.1002/14651858.CD000249.pub2

1. Antifibrinolytic agent vs control: menstrual blood loss.

Study Comparison Outcome Intervention group Control group Finding (e.g. P value for difference between groups, as reported in primary study)
Intervention n Result (mean (SD)) Intervention n Result (mean (SD))  
Jaisamrarn 2006 TXA vs progestogens or NSAIDs PBAC score TXA 3 g daily 56 204.4 (SD 255.7) Norethisterone 10 mg daily (luteal phase) 56 298.7 (SD 141.3) P < 0.0001
Mefenamic acid 1.5 mg daily 56 278.3 (SD 164.2) P < 0.001
Preston 1995 TXA vs luteal phase MPA Mean loss by alkaline haematin method (end score) TXA 4 g daily 25 97 (SD 89) Norethisterone (21 participants) 5 mg taken twice daily on days 19 to 26 of cycle. 21 208 (SD 135) P = 0.001