Cochrane Library (Wiley)

#1 MeSH descriptor: [Prostatic Neoplasms] explode all trees #2 MeSH descriptor: [Prostatic Intraepithelial Neoplasia] explode all trees #3 (prostat*):ti,ab,kw near/3 (cancer* or carcinoma* or malignan* or tumor* or tumour* or neoplas* or intraepithelial or adeno*):ti,ab,kw #4 (#1 or #2 or #3) #5 MeSH descriptor: [Cryotherapy] explode all trees #6 MeSH descriptor: [Cryosurgery] explode all trees #7 MeSH descriptor: [Hypothermia, Induced] explode all trees #8 (cryo* or hypotherm* or freez*):ti,ab,kw near/3 (prostat*):ti,ab,kw (cryo* or hypotherm* or freez*):ti,ab,kw near/3 (prostat*):ti,ab,kw #9 (#5 or #6 or #7 or #8) #10 (#4 and #9)

MEDLINE (Ovid)

1 Cryotherapy/ 2 Cryosurgery/ 3 Hypothermia, Induced/ 4 ((cryo* or hypotherm* or freez*) adj3 prostat*).tw. 5 cryoablat*.tw. 6 or/1‐5 7 exp Prostatic Neoplasms/ 8 prostatic intraepithelial neoplasia/ 9 (prostat* adj3 (cancer* or carcinoma* or malignan* or tumo?r* or neoplas* or intraepithelial or adeno*)).tw. 10 or/7‐9 11 6 and 10 12 randomized controlled trial.pt. 13 controlled clinical trial.pt. 14 randomized.ab. 15 placebo.ab. 16 drug therapy.fs. 17 randomly.ab. 18 trial.ab. 19 groups.ab. 20 or/12‐19 21 exp animals/ not humans.sh. 22 20 not 21 23 11 and 22 24 limit 23 to yr="2006 ‐Current"

EMBASE (Ovid)

1. exp prostate cancer/ 2. exp prostate carcinoma/ 3. exp prostate adenocarcinoma/ 4. exp Prostatic Intraepithelial Neoplasia/ 5. exp prostate tumor/ 6. exp prostate adenoma/ 7. (prostat* adj3 (cancer* or carcinoma* or neoplas* or tumo?r* or malignan*)).tw. 8. or/1‐7 9. cryotherapy/ 10. cryosurgery/ 11. induced hypothermia/ 12. ((cryo* or hypotherm* or freez*) adj3 prostat*).tw. 13. cryoablat*.tw. 14. cryoablation/ 15. or/9‐14 16. Crossover Procedure/ 17. double‐blind procedure/ 18. randomized controlled trial/ 19. single‐blind procedure/ 20. (random* or factorial* or crossover* or cross over* or placebo* or assign* or allocat* or volunteer*).mp. 21. ((doubl* or singl*) adj blind*).mp. 22. or/16‐21 23. 8 and 15 and 22 24. limit 23 to yr="2006 ‐Current"

ISI Web of Science (Thompson Reuters)

# 1 TS= clinical trial* OR TS=research design OR TS=comparative stud* OR TS=evaluation stud* OR TS=controlled trial* OR TS=follow‐up stud* OR TS=prospective stud* OR TS=random* OR TS=placebo* OR TS=(single blind*) OR TS=(double blind*) # 2 TS=(cryo* or hypotherm* or freez*) # 3 TS=(prostat* SAME (cancer* or carcinoma* or tumor* or tumour* or neoplas* or malignan*)) # 4 #3 AND #2 AND #1

LILACS

(mh:(prostatic neoplasms)) OR (mh:(prostatic neoplasms, castration resistant)) OR (tw:(prostat*)) AND (mh:(cryotherapy)) OR (mh:(hypothermia, induced)) OR (tw:(cryo* or hypotherm* or freez* crioterapia or criocirugia or hipotermia or congel*))

Scopus

TITLE‐ABS‐KEY(cryo* or hypotherm* or freez*) AND TITLE‐ABS‐KEY (prostat*) AND TITLE‐ABS‐KEY (cancer* OR carcinoma* OR tumor* OR tumour* OR neoplas* OR malignan*) AND TITLE‐ABS‐KEY (rct OR random*)

PUBMED

#1 ((prostatic neoplasms[MeSH Terms] OR prostatic intraepithelial neoplasia[MeSH Terms])) #2 ((prostat*) AND (cancer* OR carcinoma* OR malignan* OR tumor* OR tumour* OR neoplas* OR intraepithelial OR adeno*)) #3 (#1 or #2) #4 ((cryotherapy[MeSH Terms] OR cryosurgery[MeSH Terms] OR hypothermia, induced[MeSH Terms] OR cryo* OR hypotherm* OR freez*) #5 ((randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized[tiab] OR placebo[tiab] OR clinical trials[MeSH Terms] OR randomly[tiab] OR trial[ti])) #6 (#3 and #4 and #5) #7 MEDLINE[sb] #8 (#6 NOT #7)

OpenGrey

‘Cryotherapy’ ‐ records scanned for relevance.

WHO ICTRP

1. Prostate and cryotherapy 2. Prostate and cryosurgery 3. Prostate and cryoablation

Clinicaltrials.gov

1. Prostate and cryotherapy 2. Prostate and cryosurgery 3. Prostate and cryoablation