Comparison 2.

Prophylactic administration of paracetamol (oral or IV) versus placebo (IV) or no intervention

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure of ductal closure after 4 to 5 days of treatment	2	80	Risk Ratio (M‐H, Fixed, 95% CI)	0.49 [0.24, 1.00]
2 Death	2	80	Risk Ratio (M‐H, Fixed, 95% CI)	0.35 [0.04, 3.20]
3 Oliguria (< 1 mL/kg/h)	1	48	Risk Ratio (M‐H, Fixed, 95% CI)	0.78 [0.29, 2.11]
4 Polyuria (> 5 mL/kg/h)	1	48	Risk Ratio (M‐H, Fixed, 95% CI)	0.72 [0.31, 1.72]
5 Hypernatraemia (> 150 µmol/L)	1	48	Risk Ratio (M‐H, Fixed, 95% CI)	0.45 [0.19, 1.09]
6 Sepsis	1	48	Risk Ratio (M‐H, Fixed, 95% CI)	1.45 [0.36, 5.79]
7 Supplemental oxygen at 28 days	1	48	Risk Ratio (M‐H, Fixed, 95% CI)	0.69 [0.32, 1.48]
8 Supplemental oxygen at 36 weeks' PMA	1	48	Risk Ratio (M‐H, Fixed, 95% CI)	0.36 [0.02, 8.45]
9 ROP (treated)	1	48	Risk Ratio (M‐H, Fixed, 95% CI)	3.25 [0.14, 76.01]
10 IVH grades 1 to 2	1	48	Risk Ratio (M‐H, Fixed, 95% CI)	0.60 [0.24, 1.54]
11 IVH grades 3 to 4	1	48	Risk Ratio (M‐H, Fixed, 95% CI)	1.09 [0.07, 16.39]
12 NEC stage 3	1	48	Risk Ratio (M‐H, Fixed, 95% CI)	0.36 [0.02, 8.45]
13 Days of supplemental oxygen	1	48	Mean Difference (IV, Fixed, 95% CI)	‐2.40 [‐16.41, 11.61]
14 Highest serum bilirubin µmol/L	1	48	Mean Difference (IV, Fixed, 95% CI)	1.0 [‐10.35, 12.35]