Methods | Randomised blinded placebo controlled trial |
Participants | Preterm infants born at < 33 weeks' PMA with a haemodynamically significant PDA (diameter > 1.5 mm with clinical symptoms). were treated with a 5‐day course of oral paracetamol or placebo |
Interventions | Infants were treated with a 5‐day course of oral paracetamol (n = 27) or placebo (n = 28) |
Outcomes | Primary outcome: ductal closure by 48 h after treatment completion and decrease in size > 25% was a secondary outcome |
Notes | By early January 2018 the study has only been reported in abstract form, with insufficient information to allow us to include the study in our update of the review. |
BPD = Bronchopulmonary dysplasia
CLD = Chronic lung disease
CRP = C‐reactive protein
ECHO = Echocardiogram
IVH = Intraventricular haemorrhage
LA/AO ratio = Left atrium/aorta ratio
MDI = Mental Developmental Index
MRI = Magnetic resonance imaging
NEC = Necrotizing enterocolitis
NICHD = National Institute of Child Health and Development
NSID = Nonsteroidal anti‐inflammatory drugs
PDA = Patent ductus arteriosus
PDI = Psychomotor Developmental Index
PMA = Post Menstrual Age
PPHN = Persistent Pulmonary Hypertension of the Newborn
PVL = Periventricular leukomalacia
ROP = Retinopathy of Prematurity