ACTRN12616001517460

Trial name or title	Early PARacetamol (EPAR) to promote early closure of the ductus arteriosus in preterm infants
Methods	Not clearly stated
Participants	Preterm infants < 6 h old. Born at < 29 weeks' PMA with PDA (ductus arteriosus characteristics ‒ patent > 1 mm ‒ < 30% right to left shunt)
Interventions	"Early treatment of patent ductus arteriosus with paracetamol and to examine the safety and efficacy profile of paracetamol during the early postnatal period. We hypothesise that early treatment with paracetamol will reduce the number of infants requiring intervention for PDA and that the use of paracetamol in preterm infants with a patent ductus arteriosus will result in a higher rate of ductal closure compared with placebo. We also aim to show that paracetamol can be used safely in preterm infants during the early postnatal period".
Outcomes	Closure of PDA (not clearly defined)
Starting date	November 2016
Contact information	DR. Timothy Schindler, Department of Newborn Care Royal Hospital for Women Barker St Randwick NSW 2031, Australia (tschindl@med.usyd.edu.au)
Notes