NCT01291654

Trial name or title	Paracetamol and patent ductus arteriosus (PDA)
Methods	Randomised controlled trial
Participants	Preterm infants with a haemodynamically significant PDA
Interventions	Group 1: paracetamol orally at a dose of 15 mg/kg every 6 h × 3 days. Group 2: indomethacin intravenously 0.2 mg/kg/dose for 3 doses
Outcomes	Primary outcome: closure of the ductus within 3 days. Secondary outcomes: absence of peripheral vasoconstriction, Doppler flow velocity in the anterior cerebral artery, superior mesenteric artery and renal artery before and after pharmacological treatment, absence of hepatotoxicity
Starting date	6 February 2011
Contact information	Cathy Hammerman, Shaare Zedek Medical centre, Israel. cathy@cc.huji.ac.il
Notes	ClinicalTrials.gov identifier: NCT01291654