NTR5423

Trial name or title	Embryo SELECtion using TIme‐lapse MOnitoring in IVF and ICSI patients
Methods	Multi‐centre randomised controlled trial
Participants	Women scheduled for a single embryo transfer (SET) during their first IVF or ICSI cycle at any of the participating IVF centers will be considered for inclusion.
Interventions	A) embryo selection based on Eeva results and continuous culture in Geri+ incubator (Geri+Eeva complete), and B) routine embryo selection based on morphology and continuous culture in Geri+ incubator (Geri culture only), will be compared to C) routine embryo selection based on morphology and interrupted culture in Geri+ incubator (control). Embryos in all three groups will be cultured in the Geri+ time‐lapse incubator.
Outcomes	Primary outcomes are the ongoing pregnancy rate of the first fresh SET and the cumulative ongoing pregnancy rate including the first fresh SET and all subsequent cryo transfers from the same ovum pick up cycle within one year. Secondary outcomes are biochemical pregnancy rate and live birth rate after fresh SET, cumulative live birth rate, miscarriage rate, time to pregnancy, embryo morphology and number of usable embryos (ie embryos used for transfer or cryopreservation), morphokinetic parameters, pregnancy rates in three female age groups, cost‐efficiency, outcome of manual time‐lapse annotations.
Starting date	1 March 2017
Contact information	D.C. Kieslinger. d.kieslinger@vumc.nl
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