7.2. Analysis.
Comparison 7 Non‐comparative studies: proportion of participants with non‐serious adverse events, Outcome 2 Central nervous system.
| Central nervous system | ||
|---|---|---|
| Study | Symptom | Adverse events/total number of participants |
| Affect lability | ||
| Sahin 2014 | Moodiness | 10/30 |
| Wigal 2013 | Affect lability | 12/44 |
| Aggression | ||
| Barrickman 1995 | Anger | 1/15 |
| Berek 2011 | Aggressive reaction | 13/762 |
| Davari‐Ashtiani 2010 | Aggression | 1/16 |
| Dittmann 2014 | Aggression | 0/195 |
| Döpfner 2011a, OBSEER | Aggression | 31/777 |
| Döpfner 2011b | Aggression | 2/113 |
| Haertling 2015 | Aggression | 3/239 |
| Kemner 2005 (FOCUS) | Aggression | 10/850 |
| Kordon 2011 | Aggression | 10/541 |
| Lee 2014 | Aggression | 7/100 |
| Mayes 1994 | Aggression | 1/69 |
| Na 2013 | Anger | 6/103 |
| Remschmidt 2005 | Aggression | 1/105 |
| Wilens 2005 | Hostility | 8/407 |
| Anorexia | ||
| Arabgol 2015 | Anorexia | 8/15 |
| Arnold 2004 | Anorexia | 16/76 |
| Arnold 2010 | Anorexia | 6/150 |
| Berek 2011 | Anorexia | 35/762 |
| Cortese 2015 | Anorexia | 9/1426 |
| Döpfner 2011a, OBSEER | Anorexia | 9/777 |
| Döpfner 2011b | Anorexia | 0/113 |
| Gerwe 2009 | Anorexia | 20/263 |
| Greenhill 1983 | Anorexia | 5/7 |
| Haertling 2015 | Anorexia | 11/239 |
| Khajehpiri 2014 | Anorexia | 45/71 |
| Kordon 2011 | Anorexia | 23/541 |
| Kratochvil 2002 | Anorexia | 6/25 |
| Lee 2007 | Anorexia | 29/110 |
| Na 2013 | Anorexia | 66/103 |
| Song 2012 | Anorexia | 104/116 |
| Wang 2007 | Anorexia | 42/166 |
| Warshaw 2010 | Anorexia | 9/260 |
| Weiss 2007 | Anorexia | 16/79 |
| Wilens 2006 | Anorexia | 22/220 |
| Yildiz 2011 | Anorexia | 9/11 |
| Zelnik 2015 | Anorexia | 36/128 |
| Çetin 2015 | Anorexia | 12/61 |
| Anxiety | ||
| Abbasi 2011 | Anxiety | 9/20 |
| Akhondzadeh 2003 | Anxiety | 3/10 |
| Akhondzadeh 2004 | Anxiety | 3/20 |
| Amiri 2008 | Anxiety, nervousness | 4/27 |
| Barrickman 1995 | Anxiety | 1/15 |
| Blader 2010 | Anxiety or nervousness | 12/65 |
| Davari‐Ashtiani 2010 | Phobia & anxiety | 2/16 |
| Efron 1997 | Anxiousness | 76/123 |
| El‐Fiky 2014 | Anxious | 2/31 |
| Gau 2006 | Anxious | 10/32 |
| Ghanizadeh 2012 | Anxiety | 1/12 |
| Green 2011 | Anxiousness | 4/14 |
| Hammerness 2009 | Anxiety | 2/57 |
| Hazell 2003 | Anxious | 6/10 |
| Jafarinia 2012 | Anxiety | 5/20 |
| Maia 2008 | Anxious | 12/31 |
| Mohammadi 2004 | Anxiety | 0/11 |
| Mohammadi 2010 | Anxiety | 9/19 |
| Na 2013 | Anxiety | 9/103 |
| Song 2012 | Anxiety | 12/116 |
| Wilens 2005 | Anxiety | 9/407 |
| Zelnik 2015 | Anxiety | 21/128 |
| Fingernail biting | ||
| Blader 2010 | Bites fingernails | 9/65 |
| Efron 1997 | Biting fingernails | 56/123 |
| El‐Fiky 2014 | Bites fingers | 0/31 |
| Gau 2006 | Biting fingernails | 8/32 |
| Green 2011 | Biting fingernails | 3/14 |
| Hazell 2003 | Biting fingernails | 2/10 |
| Maia 2008 | Bites fingernails | 3/31 |
| Sahin 2014 | Nail biting | 3/30 |
| Shang 2015 | Nail biting | 1/66 |
| Daydreams | ||
| Efron 1997 | Daydreams | 77/123 |
| Gau 2006 | Daydreams | 10/32 |
| Green 2011 | Daydreams | 3/14 |
| Sahin 2014 | Daydreams | 7/30 |
| Difficulty falling asleep | ||
| Akhondzadeh 2003 | Difficulty falling asleep | 4/10 |
| Akhondzadeh 2004 | Difficulty falling asleep | 6/20 |
| Altin 2013 | Insomnia | 5/71 |
| Amiri 2008 | Difficulty falling asleep | 8/30 |
| Ardic 2014 | Insomnia | 19/101 |
| Arnold 2004 | Insomnia | 16/76 |
| Arnold 2010 | Insomnia | 9/171 |
| Atzori 2009 | Insomnia | 3/129 |
| Barrickman 1995 | Insomnia | 1/15 |
| Berek 2011 | Insomnia | 59/762 |
| Blader 2010 | Insomnia | 21/65 |
| Chou 2012b | Insomnia | 25/230 |
| Cortese 2015 | Insomnia | 31/1426 |
| Coşkun 2010 | Sleep problems | 4/7 |
| Davari‐Ashtiani 2010 | Sleep problems | 7/16 |
| Döpfner 2011a, OBSEER | Initial insomnia | 11/777 |
| Döpfner 2011b | Initial insomnia | 3/113 |
| Efron 1997 | Trouble sleeping | 79/123 |
| El‐Fiky 2014 | Insomnia | 2/31 |
| Famularo 1987 | Later sleep onset | 1/10 |
| Garg 2014 | Insomnia | 1/27 |
| Gau 2006 | Insomnia or trouble sleeping | 15/32 |
| Germinario 2013 | Insomnia | 1/9 |
| Gerwe 2009 | Difficulty falling asleep | 73/263 |
| Grcevich 2001 | Sleep problems | 7/75 |
| Green 2011 | Trouble sleeping | 7/34 |
| Greenhill 1983 | Insomnia | 2/7 |
| Gucuyener 2003 | Difficulty falling asleep | 19/119 |
| Haertling 2015 | Insomnia | 3/239 |
| Hazell 2003 | Sleep problems | 7/10 |
| Işeri 2007 | Sleep problems | 5/20 |
| Jafarinia 2012 | Insomnia | 10/20 |
| Jensen 1999 (MTA) | Insomnia | 12/245 |
| Johnson 2013 | Insomnia (new onset) | 12/45 |
| Jung 2007 | Insomnia | 16/83 |
| Kemner 2005 (FOCUS) | Insomnia | 53/850 |
| Khajehpiri 2014 | Insomnia | 44/71 |
| Kim 2010 | Insomnia | 6/24 |
| Kordon 2011 | Insomnia | 46/541 |
| Kratochvil 2002 | Insomnia | 7/25 |
| Lee 2007 | Insomnia | 24110 |
| Li 2011 | Difficulty falling asleep | 9/34 |
| Maayan 2009 | Trouble sleeping | 3/8 |
| Maia 2008 | Insomnia | 5/31 |
| Mayes 1994 | Insomnia | 9/63 |
| McCracken 2016 | Insomnia | 20/61 |
| Miller‐Horn 2008 | Insomnia | 2/23 |
| Mohammadi 2004 | Difficulty falling asleep | 4/11 |
| Mohammadi 2010 | Trouble sleeping | 9/19 |
| Mohammadi 2012a | Difficulty falling asleep | 8/23 |
| Mohammadi 2012b | Insomnia | 9/20 |
| Montañés‐Rada 2012 | Insomnia | 5/40 |
| Na 2013 | Trouble sleeping | 37/103 |
| Peyre 2012a | Insomnia | 21/121 |
| Remschmidt 2005 | Insomnia | 3/89 |
| Sahin 2014 | Difficulty falling asleep | 16/30 |
| Sangal 2006 | Insomnia | 21/79 |
| Shang 2015 | Insomnia | 12/66 |
| Song 2012 | Insomnia | 44/116 |
| Steele 2006 | Insomnia | 12/60 |
| Su 2015 | Insomnia | 20/205 |
| Tasdelen 2015 | Insomnia | 1/17 |
| Thorell 2009 | Difficulties falling asleep | 15/79 |
| Tomás Vila 2010b | Difficulty falling asleep | 45/114 |
| Valdizán Usón 2004 | Initial insomnia | 11/155 |
| Wang 2007 | Insomnia | 9/166 |
| Warshaw 2010 | Difficulty falling asleep | 25/260 |
| Weiss 2007 | Insomnia | 13/79 |
| Wigal 2013 | Insomnia | 9/39 |
| Wigal 2015 | Insomnia | 24/200 |
| Wilens 2005 | Insomnia | 81/229 |
| Wilens 2006 | Insomnia | 16/220 |
| Wilens 2008 | Insomnia | 25/127 |
| Yatsuga 2014 | Insomnia | 4/50 |
| Yildiz 2010 | Difficulty sleeping | 15/47 |
| Yildiz 2011 | Insomnia | 7/11 |
| Zarinara 2010 | Insomnia | 10/18 |
| Zelnik 2015 | Insomnia | 31/128 |
| Zeni 2007 | Insomnia | 21/106 |
| Zheng 2011 | Insomnia | 145/1154 |
| Zheng 2015 | Insomnia | 3/123 |
| Çetin 2015 | Insomnia | 5/61 |
| Depression | ||
| Atzori 2009 | Vegetative symptoms | 4/134 |
| Cherland 1999 | Mood symptoms or mood‐congruent psychotic symptoms | 11/98 |
| Döpfner 2011a, OBSEER | Depressed mood | 13/777 |
| Grcevich 2001 | Depression | 1/75 |
| Haertling 2015 | Depression | 1/262 |
| Kratochvil 2002 | Depression | 2/25 |
| Na 2013 | Depression | 9/103 |
| Song 2012 | Depression | 5/116 |
| Valdizán Usón 2013 | Depressive symptoms | 7/689 |
| Weiss 2007 | Depression | 5/79 |
| Wilens 2005 | Depression | 6/407 |
| Yildiz 2010 | Depressive symptoms | 4/47 |
| Yildiz 2011 | Depression | 3/11 |
| Disturbed sleep | ||
| Abbas 2006 | Sleeping problems | 4/90 |
| Abbasi 2011 | Trouble sleeping | 10/20 |
| Arabgol 2015 | Disturbed sleep | 4/15 |
| Arnold 2010 | Insomnia | 9/150 |
| Blader 2010 | Early waking | 6/65 |
| Efron 1997 | Trouble sleeping | 79/123 |
| Findling 2009 | Insomnia | 29/157 |
| Galland 2010 | Restless sleep | 14/27 |
| Gau 2008 | Poor sleep quality | 37/607 |
| Haertling 2015 | Sleep disorder | 1/239 |
| Hammerness 2009 | Insomnia | 7/57 |
| Hazell 2003 | Nightmares | 8/10 |
| Işeri 2007 | Sleep problems | 5/20 |
| Kim 2010 | Insomnia | 6/27 |
| Kim 2011 | Poor sleep | 8/97 |
| Mohammadi 2004 | Disturbed sleep | 4/11 |
| Montañés‐Rada 2012 | Insomnia | 5/40 |
| Perera 2010 | Poor sleep | 13/102 |
| Remschmidt 2005 | Delayed sleep | 1/105 |
| Steele 2006 | Sleep disorder | 3/60 |
| Su 2015 | Poor quality sleep | 1/205 |
| Valdizán Usón 2013 | Sleep disorder | 33/689 |
| Yildiz 2011 | Insomnia | 7/11 |
| Zheng 2015 | Poor sleep quality | 3/149 |
| Dizziness | ||
| Abbasi 2011 | Dizziness | 8/20 |
| Blader 2010 | Dizzy | 1/65 |
| Chou 2012b | Dizziness | 9/230 |
| Cortese 2015 | Dizziness | 5/1426 |
| Davari‐Ashtiani 2010 | Dizziness | 0/16 |
| Döpfner 2011b | Dizziness | 1/113 |
| Efron 1997 | Dizziness | 15/123 |
| El‐Fiky 2014 | Dizziness | 0/31 |
| Green 2011 | Dizziness | 3/14 |
| Haertling 2015 | Dizziness | 1/239 |
| Hammerness 2009 | Dizziness | 4/57 |
| Hazell 2003 | Dizziness | 7/9 |
| Jafarinia 2012 | Dizziness | 1/20 |
| Kemner 2005 (FOCUS) | Dizziness | 7/850 |
| Kim 2010 | Dizziness | 2/27 |
| Lee 2007 | Dizziness | 5/110 |
| Li 2011 | Dizziness | 4/34 |
| Maia 2008 | Dizziness | 3/39 |
| McCracken 2016 | Dizziness | 6/61 |
| Mohammadi 2004 | Dizziness | 2/11 |
| Mohammadi 2012b | Dizziness | 2/20 |
| Na 2013 | Dizziness | 11/103 |
| Pierce 2010 | Dizziness | 2/71 |
| Sahin 2014 | Dizziness | 6/30 |
| Shang 2015 | Dizziness | 1/66 |
| Song 2012 | Dizziness | 15/116 |
| Wang 2007 | Dizziness | 12/166 |
| Wilens 2005 | Dizziness | 7/407 |
| Yildiz 2010 | Dizziness | 2/47 |
| Drowsiness | ||
| Barrickman 1995 | Drowsiness | 1/15 |
| Efron 1997 | Drowsiness | 22/123 |
| El‐Fiky 2014 | Drowsiness | 2/31 |
| Garg 2014 | Drowsiness | 1/27 |
| Gau 2006 | Drowsiness | 6/32 |
| Germinario 2013 | Drowsiness | 1/9 |
| Ghanizadeh 2012 | Drowsiness | 2/12 |
| Green 2011 | Drowsiness | 2/14 |
| Hazell 2003 | Drowsiness | 7/10 |
| Kratochvil 2002 | Somnolens | 0/40 |
| Lyon 2010 | Drowsiness | 2/10 |
| Maia 2008 | Drowsiness | 1/39 |
| Sahin 2014 | Drowsiness | 8/30 |
| Song 2012 | Somnolence | 6/116 |
| Wilens 2005 | Somnolence | 10/407 |
| Wilens 2006 | Somnolence | 3/220 |
| Yildiz 2011 | Somnolence | 1/11 |
| Dysthymia | ||
| Haertling 2015 | Dysphemia | 1/239 |
| Mohammadi 2004 | Dysphemia | 0/16 |
| Emotional lability | ||
| Ardic 2014 | Emotional change | 22/101 |
| Davari‐Ashtiani 2010 | Emotional lability | 0/16 |
| Findling 2009 | Emotional lability | 5/157 |
| Hammerness 2009 | Moody | 2/57 |
| Kemner 2005 (FOCUS) | Emotional disturbance | 5/850 |
| Kordon 2011 | Emotional lability | 8/598 |
| Kratochvil 2002 | Emotional lability | 2/25 |
| Maayan 2009 | Emotional lability | 2/8 |
| McCracken 2016 | Affect lability | 14/61 |
| Silva 2004 | Emotional lability | 4/22 |
| Steele 2006 | Emotional lability | 9/60 |
| Warshaw 2010 | Affect lability | 18/260 |
| Weiss 2007 | Emotional lability | 3/79 |
| Wigal 2013 | Affect lability | 10/39 |
| Wilens 2005 | Emotional lability | 1/229 |
| Yildiz 2010 | Emotional lability | 12/47 |
| Euphoria/hypomania | ||
| Blader 2010 | Unusually happy | 12/65 |
| El‐Fiky 2014 | Euphoria | 0/31 |
| Gau 2006 | Euphoric | 3/32 |
| Grcevich 2001 | Agitation | 2/75 |
| Green 2011 | Unusually happy | 0/14 |
| Kim 2010 | Euphoria | 1/27 |
| Maia 2008 | Euphoric | 2/39 |
| Mohammadi 2004 | Euphoria or hypomania | 0/16 |
| Sahin 2014 | Ecstasy | 8/30 |
| Asthenia and fatigue | ||
| Abbasi 2011 | Fatigue | 13/20 |
| Arnold 2004 | Asthenia | 7/76 |
| Blader 2010 | Tired + low energy | 4/65 |
| Davari‐Ashtiani 2010 | Tiredness | 0/16 |
| Dittmann 2014 | Fatigue | 0/195 |
| Döpfner 2011b | Fatigue | 0/113 |
| Galland 2010 | Daytime sleepiness | 2/27 |
| Garg 2014 | Fatigue | 2/27 |
| Haertling 2015 | Asthenia | 1/239 |
| Kemner 2005 (FOCUS) | Fatigue | 3/850 |
| Lee 2007 | Fatigue | 5/110 |
| McCracken 2016 | Fatigue | 5/61 |
| Mohammadi 2010 | Fatigue | 4/19 |
| Na 2013 | Fatigue | 13/103 |
| Pierce 2010 | Fatigue | 3/71 |
| Sangal 2006 | Fatigue | 3/79 |
| Steele 2006 | Fatigue | 7/60 |
| Wang 2007 | Fatigue | 5/166 |
| Wigal 2015 | Fatigue | 10/200 |
| Headache | ||
| Abbas 2006 | Headache | 2/90 |
| Abbasi 2011 | Headache | 12/20 |
| Akhondzadeh 2003 | Headache | 6/10 |
| Akhondzadeh 2004 | Headache | 9/20 |
| Altin 2013 | Headache | 3/25 |
| Amiri 2008 | Headache | 7/27 |
| Ardic 2014 | Headache | 16/101 |
| Arnold 2004 | Headache | 24/76 |
| Arnold 2010 | Headache | 12/150 |
| Atzori 2009 | Headache | 6/129 |
| Barrickman 1995 | Headache | 1/15 |
| Berek 2011 | Headache | 15/762 |
| Blader 2010 | Headache | 1/65 |
| Chou 2012b | Headache | 7/230 |
| Cortese 2015 | Headache | 62/1426 |
| Dirksen 2002 | Headache | 17/287 |
| Dittmann 2014 | Headache | 1/195 |
| Döpfner 2011a, OBSEER | Headache | 9/777 |
| Döpfner 2011b | Headache | 8/113 |
| Efron 1997 | Headache | 30/123 |
| El‐Fiky 2014 | Headache | 4/31 |
| Findling 2009 | Headache | 54/157 |
| Galland 2010 | Morning headache | 3/27 |
| Garg 2014 | Headache | 4/27 |
| Gau 2006 | Headache | 11/32 |
| Gau 2008 | Headache | 21/607 |
| Gerwe 2009 | Headache | 15/263 |
| Goez 2012 | Headache | 4/28 |
| Golubchik 2011 | Headache | 2/9 |
| Green 2011 | Headache | 8/14 |
| Greenberg 1987 | Headache | 1/49 |
| Greenhill 1983 | Headache | 2/7 |
| Gucuyener 2003 | Headache | 14/119 |
| Guerreiro 1996 | Headache | 2/22 |
| Haertling 2015 | Headache | 2/239 |
| Hammerness 2009 | Headache | 14/57 |
| Hazell 2003 | Headache | 8/10 |
| Hulvershorn 2012 | Headache | 1/25 |
| Işeri 2007 | Headache | 5/20 |
| Jafarinia 2012 | Headache | 10/20 |
| Jung 2007 | Headache | 8/83 |
| Kemner 2005 (FOCUS) | Headache | 33/850 |
| Khajehpiri 2014 | Headache | 7/71 |
| Kim 2010 | Headache | 3/27 |
| Kordon 2011 | Headache | 14/541 |
| Kratochvil 2002 | Headache | 13/25 |
| Lee 2007 | Headache | 16/110 |
| Lee 2014 | Headache | 6/100 |
| Li 2011 | Headache | 3/34 |
| Maayan 2009 | Headache | 1/11 |
| Maia 2008 | Headaches | 4/39 |
| Mayes 1994 | Headache | 3/63 |
| McCracken 2016 | Headache | 23/61 |
| Miller‐Horn 2008 | Headache | 1/23 |
| Mohammadi 2004 | Headache | 7/11 |
| Mohammadi 2010 | Headache | 15/19 |
| Mohammadi 2012a | Headache | 4/23 |
| Mohammadi 2012b | Headache | 9/20 |
| Na 2013 | Headache | 32/103 |
| Perera 2010 | Headache | 13/102 |
| Peyre 2012a | Headache | 43/121 |
| Pierce 2010 | Headache | 6/71 |
| Remschmidt 2005 | Headache | 2/105 |
| Sahin 2014 | Headache | 14/30 |
| Sangal 2006 | Headache | 12/79 |
| Schulz 2010 | Headache | 9/145 |
| Shang 2015 | Headache | 14/66 |
| Silva 2004 | Headache | 4/22 |
| Song 2012 | Headache | 30/116 |
| Steele 2006 | Headache | 14/60 |
| Su 2015 | Headache | 4/205 |
| Tasdelen 2015 | Headache | 1/17 |
| Thorell 2009 | Headache | 6/79 |
| Valdizán Usón 2004 | Headache | 2/155 |
| Valdizán Usón 2013 | Headache | 11/689 |
| Wang 2007 | Headache | 16/166 |
| Warshaw 2010 | Headache | 23/260 |
| Weiss 2007 | Headache | 10/79 |
| Wigal 2013 | Headache | 7/39 |
| Wigal 2015 | Headache | 35/200 |
| Wilens 2005 | Headache | 123/229 |
| Wilens 2006 | Headache | 25/220 |
| Wilens 2008 | Headache | 27/127 |
| Yatsuga 2014 | Headache | 7/50 |
| Yildiz 2010 | Headache | 27/47 |
| Yildiz 2011 | Headache | 3/11 |
| Zarinara 2010 | Headache | 11/18 |
| Zelnik 2015 | Headache | 107/128 |
| Zheng 2011 | Headache | 143/1154 |
| Çetin 2015 | Headache | 2/61 |
| Increased need to sleep | ||
| Blader 2010 | Trouble waking | 1/65 |
| Galland 2010 | Hard to wake + difficult to wake | 14/27 |
| Mohammadi 2004 | Increased need to sleep | 5/11 |
| Mohammadi 2012a | Sleepiness | 4/23 |
| Na 2013 | Somnolence | 8/103 |
| Pierce 2010 | Somnolence | 2/71 |
| Wang 2007 | Somnolence | 6/166 |
| Zarinara 2010 | Somnolence | 3/19 |
| Involuntary movements | ||
| Balázs 2011 | Involuntary movements after methylphenidate treatment | 9/34 |
| Berek 2011 | Muscle contractions, involuntary | 34/762 |
| Blader 2010 | Shaking + tremor | 4/65 |
| Galland 2010 | Restless legs | 2/27 |
| Kordon 2011 | Muscle contraction, involuntary | 13/541 |
| Kratochvil 2002 | Hyperkinesia | 2/25 |
| Lee 2014 | Convulsion | 4/100 |
| Irritability | ||
| Abbasi 2011 | Irritability | 18/20 |
| Amiri 2008 | Irritability | 6/27 |
| Ardic 2014 | Irritability | 30/101 |
| Atzori 2009 | Irritability | 9/129 |
| Barrickman 1995 | Irritability | 1/15 |
| Blader 2010 | Irritability | 16/65 |
| Cortese 2015 | Irritabillity | 67/1426 |
| Efron 1997 | Irritable | 100/123 |
| El‐Fiky 2014 | Irritable | 6/31 |
| Findling 2009 | Irritability | 20/157 |
| Garg 2014 | Irritability | 2/27 |
| Gau 2006 | Irritable | 7/32 |
| Green 2011 | Irritability | 2/14 |
| Greenhill 1983 | Irritability | 4/7 |
| Hazell 2003 | Irritability | 3/10 |
| Işeri 2007 | Irritability | 3/20 |
| Jensen 1999 (MTA) | Irritability | 10/245 |
| Johnson 2013 | Irritability | 23/45 |
| Kemner 2005 (FOCUS) | Irritability | 7/850 |
| Khajehpiri 2014 | Irritability | 25/71 |
| Maayan 2009 | Irritability | 1/8 |
| Maia 2008 | Irritability | 10/39 |
| Mayes 1994 | Irritability | 18/63 |
| McCracken 2016 | Irritability | 12/61 |
| Mohammadi 2012a | Irritability | 10/23 |
| Na 2013 | Irritable | 16/121 |
| Sangal 2006 | Irritability | 12/79 |
| Silva 2004 | Irritability | 3/22 |
| Song 2012 | Irritability | 9/116 |
| Tasdelen 2015 | Irritability | 5/17 |
| Valdizán Usón 2004 | Irritability | 4/155 |
| Wang 2007 | Irritability | 10/166 |
| Warshaw 2010 | Irritability | 15/260 |
| Wigal 2015 | Irritability | 11/200 |
| Yildiz 2010 | Irritability | 16/47 |
| Nervousness | ||
| Arabgol 2015 | Nervousness | 5/15 |
| Berek 2011 | Nervousness | 17/762 |
| Jafarinia 2012 | Nervousness | 5/20 |
| Kordon 2011 | Nervousness | 13/541 |
| Kratochvil 2002 | Nervousness | 4/25 |
| Lee 2007 | Nervousness | 2/110 |
| Mohammadi 2010 | Nervousness | 14/19 |
| Na 2013 | Nervousness | 7/103 |
| Song 2012 | Nervousness | 9/116 |
| Steele 2006 | Nervousness | 9/60 |
| Weiss 2007 | Nervousness | 14/79 |
| Wilens 2006 | Nervousness | 6/220 |
| Yildiz 2011 | Nervousness | 9/11 |
| Çetin 2015 | Nervousness | 2/61 |
| Nightmares | ||
| Blader 2010 | Nightmares | 2/65 |
| El‐Fiky 2014 | Nightmares | 1/31 |
| Gau 2006 | Nightmares | 8/32 |
| Green 2011 | Nightmares | 1/14 |
| Khajehpiri 2014 | Nightmares | 3/71 |
| Kim 2010 | Nightmares | 1/27 |
| Maia 2008 | Nightmares | 1/31 |
| Sahin 2014 | Nightmares | 4/30 |
| Silva 2004 | Nightmares | 1/22 |
| Song 2012 | Nightmares | 10/116 |
| Tomás Vila 2010b | Nightmares | 12/114 |
| Restlessness and agitation | ||
| Blader 2010 | Restlessness | 3/65 |
| Davari‐Ashtiani 2010 | Restlessness | 4/16 |
| Dittmann 2014 | Agitation | 1/195 |
| Döpfner 2011b | Restlessness | 1/113 |
| Grcevich 2001 | Agitation | 2/75 |
| Haertling 2015 | Agitation | 2/239 |
| Khajehpiri 2014 | Agitation | 16/71 |
| Lee 2014 | Agitation | 6/100 |
| Mohammadi 2010 | Restlessness | 8/19 |
| Perera 2010 | Restlessness | 5/102 |
| Sahin 2014 | Restlessness | 9/30 |
| Steele 2006 | Agitation | 8/60 |
| Valdizán Usón 2013 | Physical activity modifications | 16/689 |
| Zarinara 2010 | Restlessness | 5/19 |
| Sadness | ||
| Abbasi 2011 | Sadness | 9/20 |
| Amiri 2008 | Sadness | 6/27 |
| Barrickman 1995 | Low mood | 1/15 |
| Blader 2010 | Crying + sadness | 17/65 |
| Davari‐Ashtiani 2010 | Sadness | 3/16 |
| Efron 1997 | Sadness or unhappiness | 69/123 |
| El‐Fiky 2014 | Sad | 3/31 |
| Garg 2014 | Sadness | 0/27 |
| Gau 2006 | Sadness | 14/32 |
| Green 2011 | Sadness | 7/14 |
| Hammerness 2009 | Sad | 1/57 |
| Hazell 2003 | Sad | 5/10 |
| Işeri 2007 | Sadness | 2/20 |
| Jensen 1999 (MTA) | Tearfulness | 6/245 |
| Johnson 2013 | Sadness | 18/45 |
| Kemner 2005 (FOCUS) | Crying | 13/850 |
| Maia 2008 | Sad | 4/31 |
| Mohammadi 2010 | Sadness | 4/19 |
| Mohammadi 2012a | Sadness | 2/23 |
| Perera 2010 | Sadness | 13/102 |
| Sahin 2014 | Sadness | 9/30 |
| Stares | ||
| Blader 2010 | Stares into space | 3/65 |
| El‐Fiky 2014 | Stares a lot | 8/31 |
| Hazell 2003 | Stares | 6/10 |
| Maia 2008 | Stares a lot or daydreams | 7/31 |
| Excessive talking | ||
| Blader 2010 | Overly talkative | 8/65 |
| Hazell 2003 | Talks too much | 5/10 |
| Khajehpiri 2014 | Speaking more | 6/71 |
| Taciturnity ('talking too little') | ||
| Blader 2010 | Less talkative | 4/65 |
| El‐Fiky 2014 | Talk less | 2/31 |
| Green 2011 | Talking little | 6/14 |
| Maia 2008 | Talk less | 9/31 |
| Tics | ||
| Ardic 2014 | Tics | 3/101 |
| Atzori 2009 | Tics | 2/129 |
| Blader 2010 | Tics | 3/65 |
| Cortese 2015 | Tics | 27/1426 |
| Davari‐Ashtiani 2010 | Tics | 1/16 |
| Döpfner 2011a, OBSEER | Tics | 100/777 |
| Döpfner 2011b | Tics | 1/113 |
| Efron 1997 | Tics | 35/123 |
| El‐Fiky 2014 | Tics or involuntary movements | 0/31 |
| Findling 2009 | Tics | 0/157 |
| Gau 2006 | Tics | 6/32 |
| Germinario 2013 | Tics | 1/9 |
| Golubchik 2011 | Motor tics exacerbation | 1/9 |
| Grcevich 2001 | Motor tics | 1/75 |
| Green 2011 | Tics | 0/14 |
| Gucuyener 2003 | Motor tics | 2/119 |
| Işeri 2007 | Tics | 3/20 |
| Johnson 2013 | Tics (new onset) | 1/45 |
| Khajehpiri 2014 | Tics | 18/71 |
| Kim 2010 | Tics | 3/27 |
| Kim 2011 | Tics | 19/97 |
| Lakic 2012 | Tics | 3/61 |
| Lee 2007 | Tics | 6/110 |
| Miller‐Horn 2008 | Tics | 2/23 |
| Mohammadi 2004 | Tics | 0/11 |
| Mohammadi 2012a | Tics | 1/23 |
| Mohammadi 2012b | Tics | 4/20 |
| Remschmidt 2005 | Tics | 7/89 |
| Sahin 2014 | Tics | 2/30 |
| Shang 2015 | Tics | 1/66 |
| Song 2012 | Tics | 7/116 |
| Su 2015 | Tourette disorder | 6/205 |
| Tasdelen 2015 | Tics | 1/17 |
| Valdizán Usón 2004 | Tics | 1/155 |
| Varley 2001 | Tics | 31/374 |
| Wilens 2005 | Twitching | 40/229 |
| Yildiz 2010 | Tics | 1/47 |
| Yildiz 2011 | Tics | 2/11 |
| Çetin 2015 | Tics | 1/16 |
| Isolation and lack of interest in others | ||
| Blader 2010 | Lack of interest | 6/65 |
| Efron 1997 | Uninterested in others | 39/123 |
| El‐Fiky 2014 | Uninterested in others | 2/31 |
| Green 2011 | Uninterested | 4/14 |
| Hazell 2003 | Uninterested | 6/10 |
| Khajehpiri 2014 | Isolation | 6/71 |
| Maia 2008 | Uninterested others | 6/31 |
| Perera 2010 | Social withdrawal | 6/102 |
| Sahin 2014 | Being in own world | 5/30 |
| Yildiz 2010 | Introversion (maybe isolation) | 5/47 |
| 'Zombie like' demeanour | ||
| Davari‐Ashtiani 2010 | Zombie like | 3/16 |
| Jensen 1999 (MTA) | Zombie like | 18/245 |
| Wilens 2005 | Apathy | 4/407 |
| Somnolence | ||
| Chou 2012b | Somnolence | 1/230 |
| Khajehpiri 2014 | Somnolence | 5/71 |
| McCracken 2016 | Somnolence | 3/61 |
| Na 2013 | Somnolence | 8/103 |
| Shang 2015 | Somnolence | 1/66 |
| Wang 2007 | Somnolence | 6/166 |
| Weiss 2007 | Somnolence | 7/79 |
| Wilens 2005 | Somnolence | 1/229 |
| Yildiz 2011 | Somnolence | 1/11 |
| Obsession | ||
| Cortese 2015 | Obsessive behaviour | 6/1426 |
| Khajehpiri 2014 | Obsession | 1/71 |
| Çetin 2015 | Obsession | 2/32 |
| Mood disorder | ||
| Cortese 2015 | Mood disorder | 49/1426 |
| Haertling 2015 | Emotional disorder of childhood | 1/239 |
| Confusional state | ||
| Haertling 2015 | Confusional state | 1/262 |
| Zelnik 2015 | Sense of dopiness | 13/128 |
| Sleep disorder | ||
| Dittmann 2014 | Sleep disorder | 6/195 |
| Döpfner 2011a, OBSEER | Sleep disorder | 9/777 |
| Su 2015 | Sleep disorder | 26/239 |
| Propensity to cry | ||
| El‐Fiky 2014 | Prone to cry | 4/31 |
| Sahin 2014 | Sudden crying | 12/30 |
| Sedation | ||
| McCracken 2016 | Sedation | 4/61 |
| Mohammadi 2010 | Sedation | 4/19 |
| Daytime sleepiness | ||
| Galland 2010 | Daytime sleepiness | 2/27 |
| Tomás Vila 2010b | Datime sleepiness | 2/114 |
| Dysphoria | ||
| Atzori 2009 | Dysphoria | 2/134 |
| Logorrhoea | ||
| Atzori 2009 | Loggorrhoea | 1/129 |
| Impaired concentration | ||
| Berek 2011 | Impaired concentration | 14/822 |
| Difficulty waking up | ||
| Galland 2010 | Difficult to wake up | 7/28 |
| Urinary incontinence | ||
| Garg 2014 | Urinary incontinence | 1/32 |
| Paralysis | ||
| Haertling 2015 | Paralysis | 1/239 |
| Affective disorder | ||
| Haertling 2015 | Affective disorder | 1/239 |
| Jumbled thoughts | ||
| Hammerness 2009 | Jumbled thoughts | 1/154 |
| Bulimia | ||
| Khajehpiri 2014 | Bulimia | 5/71 |
| Sleep late | ||
| Khajehpiri 2014 | Sleeping late | 22/71 |
| Tooth grinding | ||
| Khajehpiri 2014 | Tooth grinding | 3/71 |
| Tremor | ||
| Khajehpiri 2014 | Tremor | 2/71 |
| Stuttering | ||
| Khajehpiri 2014 | Stuttering | 4/71 |
| Flushing | ||
| Khajehpiri 2014 | Flushing | 9/71 |
| Apathy | ||
| Kordon 2011 | Apathy | 6/541 |
| Abnormal behaviour | ||
| Lee 2014 | Abnormal behaviour | 5/100 |
| Stereotypies | ||
| Mohammadi 2004 | Stereotypies | 0/16 |
| Quietness | ||
| Sahin 2014 | Quietness | 6/30 |
| EEG changes | ||
| Schmidt 2002 | Pathologic | 25/124 |
| Did not like themselves | ||
| Thorell 2009 | Does not like him‐ or herself | 10/79 |
| Sleep walking | ||
| Tomás Vila 2010b | Sleep walking | 2/114 |
| Personality and behaviour disorders | ||
| Valdizán Usón 2013 | Personality and behavior disorders | 14/633 |
| Vertigo | ||
| Yildiz 2011 | Vertigo | 3/11 |