Comparison 1. Comparative studies: number of serious adverse events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Any serious adverse events	2	72005	Risk Ratio (IV, Random, 95% CI)	1.36 [1.17, 1.57]
2 Central nervous system	2		Risk Ratio (IV, Random, 95% CI)	Subtotals only
2.1 Seizures	1	234	Risk Ratio (IV, Random, 95% CI)	1.31 [0.07, 23.74]
2.2 Psychotic disorder	1	71771	Risk Ratio (IV, Random, 95% CI)	1.36 [1.17, 1.57]
3 Cardiovascular and respiratory system			Other data	No numeric data
3.1 Arrhythmias			Other data	No numeric data
3.2 Hypertension			Other data	No numeric data
3.3 Myocardial infarction			Other data	No numeric data
3.4 Ischaemic stroke			Other data	No numeric data
3.5 Heart failure			Other data	No numeric data