Comparison 4. Non‐comparative studies: proportion of participants with serious adverse events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Any serious adverse event			Other data	No numeric data
2 Central nervous system			Other data	No numeric data
2.1 Sudden death			Other data	No numeric data
2.2 Suicide			Other data	No numeric data
2.3 Suicide attempt			Other data	No numeric data
2.4 Suicide thoughts			Other data	No numeric data
2.5 Psychotic symptoms			Other data	No numeric data
2.6 Seizure			Other data	No numeric data
2.7 Syncope			Other data	No numeric data
2.8 Tremor			Other data	No numeric data
2.9 Psychiatric problems			Other data	No numeric data
2.10 Severe depression			Other data	No numeric data
2.11 Overdose			Other data	No numeric data
2.12 Eating disorder			Other data	No numeric data
2.13 Aphasia			Other data	No numeric data
2.14 Headache			Other data	No numeric data
2.15 Neurological disorder			Other data	No numeric data
2.16 Sleep disorder			Other data	No numeric data
2.17 Mood disorder			Other data	No numeric data
2.18 Loss of consciousness			Other data	No numeric data
2.19 Family stress			Other data	No numeric data
2.20 Impotence			Other data	No numeric data
2.21 Severe aggression			Other data	No numeric data
2.22 Severe anorexia			Other data	No numeric data
2.23 Amphetamine intoxication			Other data	No numeric data
3 Cardiovascular and respiratory system			Other data	No numeric data
3.1 Respiratory, thoracic and mediastinal disorders			Other data	No numeric data
3.2 Cardiac problems			Other data	No numeric data
3.3 Tachycardia			Other data	No numeric data
3.4 Severe hypertension			Other data	No numeric data
3.5 Epistaxsis			Other data	No numeric data
3.6 Viral illness			Other data	No numeric data
4 Gastrointestinal system			Other data	No numeric data
4.1 Gastrointestinal disease			Other data	No numeric data
4.2 Liver disease			Other data	No numeric data
5 Musculoskeletal system: fractures			Other data	No numeric data
6 Immune system: autoimmune disease			Other data	No numeric data