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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Comparison 7. Non‐comparative studies: proportion of participants with non‐serious adverse events.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Non‐serious adverse events     Other data No numeric data
2 Central nervous system     Other data No numeric data
2.1 Affect lability     Other data No numeric data
2.2 Aggression     Other data No numeric data
2.3 Anorexia     Other data No numeric data
2.4 Anxiety     Other data No numeric data
2.5 Fingernail biting     Other data No numeric data
2.6 Daydreams     Other data No numeric data
2.7 Difficulty falling asleep     Other data No numeric data
2.8 Depression     Other data No numeric data
2.9 Disturbed sleep     Other data No numeric data
2.10 Dizziness     Other data No numeric data
2.11 Drowsiness     Other data No numeric data
2.12 Dysthymia     Other data No numeric data
2.13 Emotional lability     Other data No numeric data
2.14 Euphoria/hypomania     Other data No numeric data
2.15 Asthenia and fatigue     Other data No numeric data
2.16 Headache     Other data No numeric data
2.17 Increased need to sleep     Other data No numeric data
2.18 Involuntary movements     Other data No numeric data
2.19 Irritability     Other data No numeric data
2.20 Nervousness     Other data No numeric data
2.21 Nightmares     Other data No numeric data
2.22 Restlessness and agitation     Other data No numeric data
2.23 Sadness     Other data No numeric data
2.24 Stares     Other data No numeric data
2.25 Excessive talking     Other data No numeric data
2.26 Taciturnity ('talking too little')     Other data No numeric data
2.27 Tics     Other data No numeric data
2.28 Isolation and lack of interest in others     Other data No numeric data
2.29 'Zombie like' demeanour     Other data No numeric data
2.30 Somnolence     Other data No numeric data
2.31 Obsession     Other data No numeric data
2.32 Mood disorder     Other data No numeric data
2.33 Confusional state     Other data No numeric data
2.34 Sleep disorder     Other data No numeric data
2.35 Propensity to cry     Other data No numeric data
2.36 Sedation     Other data No numeric data
2.37 Daytime sleepiness     Other data No numeric data
2.38 Dysphoria     Other data No numeric data
2.39 Logorrhoea     Other data No numeric data
2.40 Impaired concentration     Other data No numeric data
2.41 Difficulty waking up     Other data No numeric data
2.42 Urinary incontinence     Other data No numeric data
2.43 Paralysis     Other data No numeric data
2.44 Affective disorder     Other data No numeric data
2.45 Jumbled thoughts     Other data No numeric data
2.46 Bulimia     Other data No numeric data
2.47 Sleep late     Other data No numeric data
2.48 Tooth grinding     Other data No numeric data
2.49 Tremor     Other data No numeric data
2.50 Stuttering     Other data No numeric data
2.51 Flushing     Other data No numeric data
2.52 Apathy     Other data No numeric data
2.53 Abnormal behaviour     Other data No numeric data
2.54 Stereotypies     Other data No numeric data
2.55 Quietness     Other data No numeric data
2.56 EEG changes     Other data No numeric data
2.57 Did not like themselves     Other data No numeric data
2.58 Sleep walking     Other data No numeric data
2.59 Personality and behaviour disorders     Other data No numeric data
2.60 Vertigo     Other data No numeric data
3 Cardiovascular and respiratory system     Other data No numeric data
3.1 Cough     Other data No numeric data
3.2 Pharyngolaryngeal pain     Other data No numeric data
3.3 Upper respiratory tract infection     Other data No numeric data
3.4 Tachycardia     Other data No numeric data
3.5 Abnormal ECG     Other data No numeric data
3.6 Nasal congestion     Other data No numeric data
3.7 Palpitation     Other data No numeric data
3.8 Systolic blood pressure     Other data No numeric data
3.9 Diastolic blood pressure     Other data No numeric data
3.10 Pulse rate     Other data No numeric data
3.11 ECG‐QT     Other data No numeric data
3.12 Cold fingers     Other data No numeric data
3.13 Sweating     Other data No numeric data
3.14 Hypertension     Other data No numeric data
3.15 Hypotension     Other data No numeric data
3.16 Respiratory, thoracic and mediastinal disorders     Other data No numeric data
3.17 Proportion of patients with micro‐nucleated (Mn) peripheral lymphocytes     Other data No numeric data
4 Gastrointestinal system     Other data No numeric data
4.1 Abdominal pain     Other data No numeric data
4.2 Constipation     Other data No numeric data
4.3 Decreased appetite     Other data No numeric data
4.4 Decreased weight     Other data No numeric data
4.5 Diarrhoea     Other data No numeric data
4.6 Dry mouth     Other data No numeric data
4.7 Gastrointestinal adverse events     Other data No numeric data
4.8 Nausea     Other data No numeric data
4.9 Upset stomach     Other data No numeric data
4.10 Vomiting     Other data No numeric data
4.11 Dyspepsia     Other data No numeric data
4.12 Gastroenteritis     Other data No numeric data
4.13 Increased appetite     Other data No numeric data
4.14 Xerostomia     Other data No numeric data
5 Musculoskeletal system     Other data No numeric data
5.1 Chest pain     Other data No numeric data
5.2 Height     Other data No numeric data
5.3 Weight     Other data No numeric data
5.4 BMI     Other data No numeric data
5.5 Height z score     Other data No numeric data
5.6 Weight z score     Other data No numeric data
5.7 BMI z score     Other data No numeric data
5.8 Increased mobility     Other data No numeric data
5.9 Bone mineral density     Other data No numeric data
6 Immune system     Other data No numeric data
6.1 Nasopharyngitis     Other data No numeric data
6.2 Pyrexia     Other data No numeric data
6.3 Allergies     Other data No numeric data
6.4 Cold symptoms     Other data No numeric data
6.5 Pharyngitis     Other data No numeric data
6.6 Viral infection     Other data No numeric data
6.7 Rash     Other data No numeric data
6.8 Rhinitis     Other data No numeric data
6.9 Ear disorders     Other data No numeric data
6.10 Fever     Other data No numeric data
6.11 Infections     Other data No numeric data
7 Urogenital system: enuresis     Other data No numeric data
8 Other body systems     Other data No numeric data
8.1 Hair loss     Other data No numeric data
8.2 Skin problems     Other data No numeric data
8.3 Accidental injury     Other data No numeric data
8.4 Voice frequency     Other data No numeric data
8.5 Hypersalivation     Other data No numeric data
8.6 Nasal bleeding     Other data No numeric data
8.7 Chromosomal aberration     Other data No numeric data