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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Dupuy 2008.

Methods A controlled before‐after study investigating the effects of stimulants on EEG coherence in girls with ADHD
Participants Number of participants screened: not stated
Number of participants included: 9
Number of participants followed up: 9
Number of withdrawals: 0
Diagnosis of ADHD: DSM‐IV (subtype: combined or Inattentive)
Age: range 7‐12 years old
IQ: > 85
Sex: female
Methylphenidate‐naïve: 100%
Ethnicity: not stated
Country: Australia
Comorbidity: none
Comedication: not stated
Sociodemographics: not stated
Inclusion criteria:
  1. ADHD according to DSM‐IV

  2. IQ > 85

  3. Positive response to stimulant medication


Exclusion criteria:
  1. History of problematic prenatal, perinatal, or neonatal periods

  2. A history of central nervous system (CNS) diseases

  3. Convulsion or convulsive disorders

  4. Evidence of a consciousness disorder

  5. Head injury with cerebral symptoms

  6. Paraxysmal headaches or tics

  7. DSM‐IV criteria for CD or ODD, an anxiety or depressive disorder, Asperger or Tourette syndrome

Interventions Methylphenidate type: not stated
Methylphenidate dosage: not stated
Administration schedule: not stated
Duration of intervention: 6 months
Treatment compliance: not stated
Outcomes Non‐serious adverse events:
If participants experienced any problems with their medication, parent(s) were asked to contact their doctor, their medication was changed, and they were removed from the study; this did not occur with these participants
Notes Sample calculation: not stated
Any withdrawals due to adverse events: none
Ethics approval: Illawarra area health/University of Wollongong Human Research Ethics Committee
Funding/vested interest: not stated
Authors' affiliations: Brain & Behaviour Research Institute and School of Psychology, University of Wollongong, Australia Sydney Developmental Clinic, Australia
Key conclusions of the study authors: intrahemispheric and interhemispheric coherences in ADHD stimulant medicated girls. Girls had elevated frontal coherence across all frequency bands
Comments from the review authors: only children who had a positive response on stimulants were included in the study. We can only use this study qualitatively and not in the analyses.
Exclusion of MPH non‐responders/children who have previously experienced adverse events on MPH: no