Ghanizadeh 2009.

Methods	A patient report of excessive talking during methylphenidate treatment
Participants	Diagnosis of ADHD: DSM‐IV (subtype: not stated) Age: 5 years old IQ: > 70 Sex: male Ethnicity: not stated Country: Iran Comorbidity: no Comedication: no Sociodemographics: not stated
Interventions	Methylphenidate type: not stated Methylphenidate dosage: 10 mg/day Administration schedule: not stated Duration of treatment: about 7 months Treatment compliance: not stated
Outcomes	Non‐serious adverse events: Mother and nursery teacher complained about increased hypertalkativity starting about 45 minutes after taking medication. The increased hyper‐talkativity continued for about 3‐4 hours. They scored hypertalkativity as 7‐9 on a 1‐10 visual analogue scale (10 is maximum) Re‐challenge was conducted more than 20 times and hyper‐talking reoccurred every time he took the medication
Notes	Ethics approval: not stated Funding/vested interests: not stated Key conclusions of study authors: this is a report of excessive talking after taking methylphenidate in a child with ADHD. Further research is necessary to study if there is any possible association