Halevy 2009.
Methods | A patient report of complex visual hallucinations during methylphenidate treatment | |
Participants | DSM‐IV‐R diagnosis of ADHD, combined type Age: 15 years old IQ: normal intelligence Sex: male Ethnicity: not stated Country: Israel Comorbidity: no (no past experience with drugs, smoking habit, or alcohol consumption. Normal physical and neurological examinations. Normal visual acuity. Electroencephalography (EEG) during a symptomatic state revealed no abnormalities and no evidence of epileptic activity) Comedication: not stated Sociodemographics: not stated |
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Interventions |
At 8 years of age: Methylphenidate type: Ritalin Methylphenidate dose: 10 mg daily (0.3 mg/kg) Administration schedule: not stated Treatment compliance: not stated Discontinuation Reintroduction of methylphenidate 7years later Methylphenidate type: not stated Methylphenidate dose: 0.15 mg/kg daily Administration schedule: not stated Treatment compliance: not stated |
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Outcomes |
Serious adverse events: Hallucinations Several days after initiation of treatment: visual hallucinations of rats, accompanied by some tactile hallucinations. Only present during the time the patient was under the influence of methylphenidate and disappeared thereafter. Discontinuation: immediate complete resolution Reintroduction of methylphenidate treatment. After 2 days: same complex visual hallucinations. Discontinuation: immediate complete resolution |
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Notes | Funding/vested interest: the authors have no conflicts of interest to disclose with regard to this article Key conclusions of the study authors: the occurrence of hallucinations after a very low dose of methylphenidate on 2 occasions may suggest an idiosyncratic reaction. The phenomenon might also be explained by a drug‐induced dysfunction of the monoamine transmitters Comments from the study authors: given the wide use of methylphenidate, clinicians should be aware of this possible side effect Supplemental information regarding IQ and diagnostic criteria received through personal email correspondence with the authors in August 2013 (Halevy 2013 [pers comm]) |