Karapinar 2014.

Methods	A patient report of sudden hearing loss associated with methylphenidate treatment
Participants	Diagnosis of ADHD: DSM‐IV (subtype: combined) Age: 8 years old IQ: > 70 Sex: female Ethnicity: not stated Country: Turkey Comorbidity: none Comedication: none Sociodemographics: not stated
Interventions	Methylphenidate type: Ritalin Methylphenidate dosage: 10 mg/day Administration schedule: 5 mg twice daily Duration of treatment: 4‐5 days Treatment compliance: yes
Outcomes	Serious adverse events: About 24 hours after taking methylphenidate the patient began feeling loss of balance, nausea, vomiting. She was kept on the medication. After third dose, her symptoms became more severe. Clinical findings suggested sensorineural hearing loss associated with drug ototoxicity in the left ear. Methylphenidate treatment was discontinued, and the hearing loss treated. At the end of the 2‐month follow‐up period, her hearing in the affected ear showed no significant improvement.
Notes	Key conclusions of the study authors: sensorineural hearing loss that occurred after the introduction of methylphenidate is a serious complication of the treatment, without resolution after discontinuation of the drug and administration of several treatments. The possibility of the development of irreversible sudden hearing loss should be borne in mind when patients are undergoing medical treatment of ADHD with methylphenidate