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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Khodadust 2012.

Methods A 6‐week randomised, double‐blind, parallel group study with 2 arms:
  1. Methylphenidate (Ritalin)

  2. Methylphenidate (Stimdate)


No control/no‐intervention group
Participants Number of participants screened: not stated
Number of participants included: 30
Number of participants randomised to Ritalin: 15 and Stimdate: 15
Number followed up in each arm: Ritalin: 14 and Stimdate: 14
Number of withdrawals in each arm: Ritalin: 1 and Stimdate: 1
Diagnosis of ADHD: DSM‐IV‐TR (subtype: combined 100%)
Age: Ritalin: 9.2 (0.5); Stimdate: 8.33 (0.5)
IQ: above 70
Sex: Ritalin: 12 males, 3 females; Stimdate: 15 females
Methylphenidate‐naïve: none
Ethnicity: 100% Persian
Comorbidity: none
Comedication: none
Sociodemographics: not stated
Inclusion criteria:
  1. 6‐16 years old

  2. Meeting the DSM‐IV diagnostic criteria for ADHD

  3. No psychological or medical treatment received in the last 4 weeks before the study

  4. Having informed written consent signed by parents for participating in the study

  5. Not having comorbid conditions including conduct disorder, pervasive developmental disorder, mood disorders, Tourette disorder, and psychotic disorders

  6. The ability to comply with the study's visits schedule


Exclusion criteria:
  1. The presence of clinically significant gastrointestinal problems, cardiovascular diseases, glaucoma, and seizure disorder

  2. Suspicion or confirmation of substance abuse by patients or a family member

  3. Presence of mental retardation according to educational history or, having an IQ score less than 70

  4. Allergy to stimulants

  5. Having to receive any psychiatric or somatic medication (except Ritalin or Stimdate) during the study

Interventions Participants were randomly assigned to 2 methylphenidate preparations: Ritalin or Stimdate
Final mean methylphenidate dose: Ritalin (29.2 (SD 9.1) mg), Stimdate (31.4 (SD 8.6) mg)
Administration schedule: morning and noon
Duration of intervention: 6 weeks
Titration period: 4 weeks initiated after randomisation
Treatment compliance: not stated
Outcomes Non‐serious adverse events:
Nonserious adverse events checklist and telephone interviews asking about drug side effects were performed
Notes Sample calculation: not stated
Ethics approval: not stated
Funding/vested interests: none declared
Key conclusions of the study authors: we recommend clinicians choose Ritalin or Stimdate according to the patient's preferences, sustained accessibility, primary response to treatment, and possible side effects encountered in course of treatment. This means that neither of these drugs has been proven to be superior to the other one
Exclusion of methylphenidate non‐responders/children who have previously experienced adverse events on methylphenidate: yes. See exclusion criteria 4
Supplemental information requested twice through email correspondence with the authors in June 2013. No reply